CAS: 6250-72-2; 18-Methylnonadecanoic Acid

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2724-58-5 4669-02-7 5963-14-4

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CAS号2104-19-0 壬二酸单甲酯 | CAS号89160-66-7 18-methylnonade... | CAS号2724-56-3 10-甲基十一烷酸 | CAS号818-88-2 癸二酸单甲酯 | CAS号59708-73-5 19-甲基二十烷酸 | CAS号59708-74-6 21-methyld°Cosa...

📜壬二酸氢甲酯置于甲醇,Sodium体系中,化学反应生成 18-甲基十九烷酸
参考文献:羊毛蜡的成分.第二部分 酸和所述的醇的合成异和(+)--反异-Series
标题:羊毛蜡的成分.第二部分 酸和所述的醇的合成异和(+)--反异-Series
摘要:
DOI:10.1039/jr9540003344

专利信息

专利号:US-2008300418-A1
优先权日:2004-11-08
标 题:Synthesis of Cardiolipin Analogues and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.

专利号:US-2017246690-A1
优先权日:2014-06-20
标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom
发明人：MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND
权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA
摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.

专利号:US-2008286351-A1
优先权日:2004-06-29
标 题:Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides synthetic methods for PEGylated cardiolipins with varying linkers. The methods can be employed to prepare PEGylated cardiolipin with different fatty acid and/or alkyl chain length with or without unsaturation. The PEGylated cardiolipin, prepared by the present methods, can be incorporated into liposomes that can also include active agents such as hydrophilic or hydrophobic drugs for the treatment of human and animal diseases. In addition, the PEGylated cardiolipin can be incorporated into liposomes that include compounds for therapeutic and diagnostic imaging. The use of such liposomes with PEGylated cardiolipin prolongs the period of liposomal circulation without disrupting the lipid bilayer.

专利号:US-2005266068-A1
优先权日:2002-05-24
标题 :Cardiolipin molecules and methods of synthesis
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.

专利号:US-6214875-B1
优先权日:1998-04-14
标题:Anticancer effects of specific branched-chain fatty acids and related production process
发明人：YANG ZHENHUA
摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

专利号:EP-1819715-A2
优先权日:2004-11-08
标 题 :Synthesis of cardiolipin analogues and uses thereof