Gamma-去氢毒芹碱置于n-氯代丁二酰亚胺,Sodium Methylate体系中,用 甲醇,四氯化碳 作为反应溶剂,化学反应 15.0H,反应生成 2-丙基吡啶 参考文献:A New Efficient Synthesis Of Pyridines 标题:A New Efficient Synthesis Of Pyridines 摘要:循环六元亚胺,即2,3,4,5-四氢吡啶,在温和条件下通过与氯代琥珀酰亚胺(ncs)进行高度区域选择性的α,α-二氯化转化为相应的吡啶,随后与甲醇碱进行双重脱氯化反应,效率很高. DOI:10.1039/cc9960000635
专利号:US-7825244-B2 优先权日:2005-06-10 标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-4801744-A 优先权日:1985-03-01 标 题 :Catalytic synthesis of urea from carbon monoxide and amine compound 发明人:HERMAN JEAN-JACQUES; LECLOUX ANDRE 权利人:SOLVAY 摘要:Process for the catalytic synthesis of nitrogen-containing organic compounds, comprising the reaction of carbon monoxide with at least one amino compound in a reaction mixture containing a catalyst based on selenium and a substituted pyridine. The process is particularly suitable for the synthesis of ureas and of their polymers.
专利号:US-6399536-B2 优先权日:2000-02-11 标 题 :High performance catalyst systems for the synthesis of alkylenecarbonates 发明人:KIM HOON SIK; LEE BYUNG GWON; LEE SANG DEUK; KWON YOUNG SOO; LEE HYUN JOO 权利人:KOREA INST SCI & TECH 摘要:A catalyst of the formula (1) for the synthesis of alkylene carbonate by reacting alkylene oxide and carbon dioxide n n n L m MX n   (1) n n n wherein L is selected from a group of pyridines; n M is a metal atom selected from Zn, Fe, Mn, Pb and In; n X is a halogen atom selected from Cl, Br and I; n m is 1 or 2, and n n is 2 or 3.
专利号:WO-2023112055-A1 优先权日:2021-12-15 标 题 :New synthetic process design for the synthesis of carboxy tormifene and purity analysis to strengthen antidoping testing 发明人:KUMAR GANGASANI JAGADEESH; PAWAR SACHIN DATTRAM; RADHAKRISHNANAND PULLAPANTHULA; MURTY UPADHYAYULA SURYANARAYANA; SAHU PURAN LAL; DUBEY SACHIN; SAHU KAPENDRA; UPADHYAY AWANISH; KUMAR PRAMOD 权利人:DIRECTOR NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RES GUWAHATI NIPER G; DIRECTOR NAT DOPE TESTING LABORATORY NDTL 摘要:The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.
专利号:US-6407264-B2 优先权日:2000-02-11 标 题:Synthesis of alkylene carbonates using a catalyst system comprising metal halide and pyridine or pyridine derivative 发明人:KIM HOON SIK; KIM JAI JUN; LEE BYUNG GWON; KIM HONG GON 权利人:KOREA INST SCI & TECH 摘要:The present invention relates to a method to prepare alkylene carbonate of the formula (1) n wherein, R 1 and R 2 are each independently H; C 1 -C 4 alkyl or phenyl group; n which method characterized by reacting alkylene oxide with carbon dioxide in the presence of a catalyst system comprising a) metal halide [MX m ] and b) pyridine or pyridine derivative [Py], wherein Py is selected from a group of pyridines; M is a metal atom selected from the group consisting of Zn, Fe, Mn, Pb and In; X is a halogen selected from the group consisting of Cl, Br and I; and m is 2 or 3.
专利号:WO-2011000481-A1 优先权日:2009-07-02 标 题 :Synthesis of pyrazine derivates 发明人:IGNATYEV NIKOLAI MYKOLA; SHEREMETEV ALEXEI B; ALEXANDROVA NATALIA S 权利人:MERCK PATENT GMBH; IGNATYEV NIKOLAI MYKOLA; SHEREMETEV ALEXEI B; ALEXANDROVA NATALIA S 摘要:The present invention relates to a method for producing pyrazine derivates, wherein the reaction medium comprises at least one ionic liquid, and to the use of ionic liquids for producing pyrazine derivates.
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