专利号:WO-02061120-A1 优先权日:2001-02-01 标题:Method of evaluating ability of drug to induce enzyme in liver cells 发明人:OHTA KUNIHIRO; NAKAGAWA TOSHITO 权利人:CHUGAI PHARMACEUTICAL CO LTD; OHTA KUNIHIRO; NAKAGAWA TOSHITO 摘要:A method of evaluating the ability of a test drug to induce the synthesis of CYP (cytochrome P450) in liver cells characterized by comprising culturing the liver cells in a culture medium containing the test drug in the presence of matrigel and evaluating the ability of the test drug to induce the synthesis of CYP by assaying the enzymatic activity of CYP in the culture medium.
专利号:US-11273138-B2 优先权日:2017-11-02 标 题 :Use of amino acid supplementation for improved muscle protein synthesis 发明人:WOLFE ROBERT R; FERRANDO ARNY 权利人:BIOVENTURES LLC 摘要:The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.
专利号:US-2012283282-A1 优先权日:2009-06-18 标题 :Photoproducts of Tryptophan, Their Synthesis and Uses Thereof 发明人:RIFKIND ARLEEN; DIANI-MOORE SILVIA; WARREN J DAVID; HALL ERIN; MA YULIANG 权利人:RIFKIND ARLEEN; DIANI-MOORE SILVIA; WARREN J DAVID; HALL ERIN; MA YULIANG 摘要:We have found that exposure of an aqueous tryptophan solution to window sunlight results in the production of multiple tryptophan photoproducts that have the capability of activating the aryl hydrocarbon receptor and increasing the production of AhR target genes and proteins in hepatocytes. We have isolated three of those photoproducts not previously identified as AhR activators, their chemical identification and synthesis and the demonstration that all three have biologic activities as novel AhR activators. Further, one of the three is a completely novel, not previously described, chemical compound.
专利号:US-2024200068-A1 优先权日:2022-12-15 标题 :RNAi-NANOPARTICLE CONJUGATE, COMPOSITION, AND METHOD OF SYNTHESIS THEREOF 发明人:GUNDLOORI RATHNA VENKATA NAGA; KUMAR LEKHA DINESH; SINGAM AMARNATH RAM 权利人:COUNCIL SCIENT IND RES 摘要:RNAi nanoparticle conjugates and compositions thereof for management of cancer include an active ingredient, a polysaccharide, an RNAi silencer, and a coating agent. The conjugates are synthesized by encapsulating an active ingredient in a polysaccharide to obtain a nanoencapsulate that is fabricated into nanoparticles. The nanoencapsulate is immobilized with an RNAi silences to obtain a complex that is coated to form the conjugate. The conjugate is non-toxic, silences EphB4 gene, and is capable of targeted cancer therapeutics with enhanced permeation. The conjugate synergistically upregulates Wnt genes by RNAi and demonstrates tumor suppressive action of the active ingredient.
专利号:US-2025017211-A1 优先权日:2021-03-01 标题 :Solid particulate pest control compositions and methods 发明人:RODRIGUEZ IAN; ROSS DOUGLAS H; REED JANIS; PATTERSON HEATHER ERSKINE; KNOX MARIE; CARESPODI JOHN 权利人:CONTROL SOLUTIONS INC 摘要:Compositions and methods for controlling pests are disclosed. The compositions comprise a solid particulate chitin synthesis inhibitor and methods of using the chitin synthesis inhibitor to control a target pest. The chitin synthesis inhibitor is active in its solid form, and provides control of current and future pest generations independent of application timing with respect to insect life stage.
专利号:US-2013164265-A1 优先权日:2011-12-21 标题 :Skin care compositions 发明人:FLAVIN DANA; OBENLAND SIGRID 权利人:FLAVIN DANA; OBENLAND SIGRID 摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.
1: Wang C, Xu CX, Bu Y, Bottum KM, Tischkau SA. Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling. Carcinogenesis. 2014 Mar;35(3):703-13. doi: 10.1093/carcin/bgt356. Epub 2013 Oct 26. 2: Chatuphonprasert W, Sangkawat T, Nemoto N, Jarukamjorn K. Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. Fitoterapia. 2011 Sep;82(6):889-95. doi: 10.1016/j.fitote.2011.05.002. Epub 2011 May 23. doi: 10.1016/j.toxlet.2010.03.019. Epub 2010 Apr 1. doi: 10.1016/j.aquatox.2016.10.023. Epub 2016 Oct 25. doi: 10.1016/j.bmc.2009.12.036. Epub 2009 Dec 21. doi: 10.1016/j.tox.2009.12.019. Epub 2010 Jan 5. doi: 10.1016/j.cbpc.2014.04.005. Epub 2014 Apr 22. doi: 10.1124/dmd.109.027342. Epub 2009 May 18. 16: Brauze D, Januchowski R, Szyfter K. Differences between rats and mice in induction of 4S beta-naphthoflavone-binding protein expression by treatment with beta-naphthoflavone. J Appl Genet. 2002;43(3):371-6. doi: 10.1124/dmd.110.034421. Epub 2010 Sep 15. doi: 10.1016/j.micpath.2009.08.004. Epub 2009 Aug 26.
合成参考文献
参考文献:10.1016/j.taap.2011.06.018 摘要:Couroucli XI, Liang YW, Jiang W, Wang L, Barrios R, Yang P, Moorthy B. Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicology and Applied Pharmacology. 2011 Oct;256(2):83–94. doi: 10.1016/j.taap.2011.06.018.