CAS: 55338-73-3; 5-Amino-2-Pyridinecarbonitrile

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24242-20-4 100367-55-3 145255-19-2

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CAS号100367-55-3 2-氰基-5-硝基吡啶 | CAS号4487-59-6 2-溴-5-硝基吡啶 | CAS号5418-51-9 2-羟基-5-硝基吡啶 | CAS号32046-43-8 5-碘吡啶-2-羧酸 | CAS号41960-47-8 2-氰基-5-碘吡啶 | CAS号327056-62-2 2-氰基-5-氟吡啶 | CAS号51460-32-3 1-(5-氨基吡啶-2-基)乙酮 | CAS号849353-22-6 5-AMINO-6-BROMO... | CAS号24242-20-4 5-氨基吡啶-2-羧酸 | CAS号771574-03-9 6-氨甲基-3-氨基吡啶 | CAS号145255-19-2 5-氨基-2-吡啶甲酰胺 | CAS号1170774-20-5 N-(6-Cyano-3-py... | CAS号917911-22-9 3-[3-(5-fluorop...

2-羟基-5-硝基吡啶置于sodium Cyanide,溴,三溴化磷,铁粉,溶剂黄146体系中,用 乙酸乙酯,1,2-二氯乙烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.5H,反应生成 3-氨基-6-氰基吡啶
参考文献:The Synthesis Of The High-Potency Sweetener,Nc-00637. Part 2: Preparation Of The Pyridine Moiety
标题:The Synthesis Of The High-Potency Sweetener,Nc-00637. Part 2: Preparation Of The Pyridine Moiety
摘要:The Pyridine Moiety Within The High-Potency Sweetener,Nc-00637 (1),5-Amino-2-Cyanopyridine (4),Was Prepared From 2-Hydroxy-5-Nitropyridine (10). The Sequence Involved The Conversion Of The Hydroxy Group To Bromide Followed By Substitution With Cyanide To Give 2-Cyano-5-Nitropyridine (8). Reduction Of The Nitro Group Proved To Be Troublesome When Catalytic Hydrogenation Was Used. Iron With An Acid Gave A Reproducible Reaction That Could Be Used At Scale.
DOI:10.1021/op034110C

专利信息

专利号:CN-117897379-A
优先权日:2021-08-30
标 题:Process for the synthesis of naphthyridine derivatives and intermediates thereof

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)

专利号:CN-105669772-A
优先权日:2016-02-23
标题 :Preparation and synthesis method of a kind of nickel complex

专利号:CN-105669710-A
优先权日:2016-02-23
标题:Preparation of a copper complex crystal and its synthesis method