CAS: 53994-69-7; (6R,7R)-7-Amino-3-Chloro-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

相似化合物

36923-17-8 79349-82-9 108260-07-7

上下游产品

CAS号53994-73-3 头孢克罗

(6R,7R)-7-(4-Carboxybutanoylamino)-3-Chloro-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylic Acid置于sodium Hydroxide,Glutaryl-7-Aminocephalosporanic Acid Acylase体系中,用 水 作为反应溶剂,化学反应生成 7-氨基-3-氯-3-头孢环-4-羧酸
参考文献:谷氨酰酰化酶:单反应酶还是多功能对映选择性生物催化剂
标题:谷氨酰酰化酶:单反应酶还是多功能对映选择性生物催化剂
摘要:用工业戊二酰-7-氨基头孢烷酸酰基转移酶(ga)已观测到跨越常规β-内酰胺衍生物的显着广泛的底物特异性.该酶具有显着的对映选择性酰胺酶和甚至酯酶活性,并具有s-对映异构体的立体偏好.通过溶剂萃取,避免在反应后处理过程中避免色谱或蒸馏,可以轻松地将具有不同物理化学性质的产物与未反应的试剂分离.
DOI:10.1002/adsc.200303013

专利信息

专利号:EP-0730036-B1
优先权日:1995-02-28
标 题:Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor
发明人：ZENONI MAURIZIO; TAGLIANI AURO R; CANNAS EMILIANO; VENTURELLI ANGELO
权利人:ACS DOBFAR SPA
摘要:A process for producing penicillins and cephalosporins by reacting a beta -lactam nucleus with an amide. The reaction is catalyzed by a penicillin acylase enzyme and takes place in the presence of enzyme inhibitors.

专利号:WO-2006069984-A3
优先权日:2004-12-27
标 题:Process for the synthesis of cefaclor

专利号:EP-0730036-A1
优先权日:1995-02-28
标 题:Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor

专利号:BR-PI0519476-B8
优先权日:2004-12-27
标 题:process for the synthesis of cefaclor and process for obtaining cefaclor

专利号:AU-699930-B2
优先权日:1995-02-28
标题 :Process for enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor

专利号:IT-MI960033-A1
优先权日:1996-01-11
标题 :PROCEDURE FOR THE ENZYMATIC SYNTHESIS OF B-LACTAM ANTIBIOTICS IN THE PRESENCE OF AN ENZYME INHIBITOR