CAS: 53813-83-5; 6-(7-Chloro-1,8-Naphthyridin-2-yl)-7-Oxo-2,3,6,7-Tetrahydro-5H-[1,4]Dithiino[2,3-C]Pyrrol-5-Yl 4-Methylpiperazine-1-Carboxylate

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    上下游产品

    6-(7-氯-1,8-萘啶-2-基)-2,3,6,7-四氢-7-羟基-5H-1,4-二噻英并[2,3-C]吡咯-5-酮 6-(7-Chloro-[1,8]Naphthyridin-2-yl)-7-Hydroxy-2,3,6,7-Tetrahydro-[1,4]Dithiino[2,3-C]Pyrrol-5-One 53788-25-3

    合成工艺路线路线简述

      📜4-甲基哌嗪-1-甲酰氯,6-(7-氯-1,8-萘啶-2-基)-2,3,6,7-四氢-7-羟基-5H-1,4-二噻英并[2,3-C]吡咯-5-酮置于4-甲基哌嗪-1-甲酰氯体系中,化学反应生成 舒立克隆
      参考文献:1,4-Dithiino(2,3-C)Pyrrole Derivatives
      标题:1,4-Dithiino(2,3-C)Pyrrole Derivatives
      摘要:新的化合物的公式为:##spc1## 其中a是苯基,吡啶基,吡嗪啉基,2-,3-或4-喹啉基或萘啉基基团,或者是该基团被卤素,烷基,烷氧基,氰基或硝基中的一个或两个原子或基团替代的基团,R是烷基,烯基或羟基烷基,N为零或1,具有药理学特性,特别是作为镇静剂,抗惊厥剂,解痉剂和催眠剂具有活性.

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      专利信息


      专利号:US-2018170867-A1
      优先权日:2015-05-08
      标 题:Stereoselective synthesis of 9-cis.13,14-dihydroretinoic acid and its ethyl esters

      专利号:EP-3294711-A1
      优先权日:2015-05-08
      标 题 :Stereoselective synthesis of 9-cis.13,14-dihydroretinoic acid and its ethyl esters

      专利号:WO-2016181288-A1
      优先权日:2015-05-08
      标题 :Stereoselective synthesis of 9-cis.13,14-dihydroretinoic acid and its ethyl esters

      专利号:ES-2379519-T3
      优先权日:2006-10-20
      标 题:N- (2-hydroxyethyl) -N-methyl-4- (quinolin-8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide, the process for its synthesis, as well as its use for the treatment of pain, anxiety and depression

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      主要参考文献


      1: Morishita H, Kushiku K, Matsuki J, Tokunaga T, Inoue T, Mori R, Kawamoto H, Furukawa T. Pharmacological effects of the antianxiety compound suriclone and its principal metabolites. Arzneimittelforschung. 1987 Dec;37(12):1332-40.
      8: Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundam Clin Pharmacol. 1992;6(6):251-8.

      合成参考文献


      参考文献:10.1007/s002689900175
      摘要:Meissner AJ, Huszcza S. Surgical strategy for management of deep venous thrombosis of the lower extremities. World J Surg. 1996 Nov;20(9):1149–55. doi: 10.1007/s002689900175.
      参考文献:10.1007/s108-002-8080-9
      摘要:Schellong SM, Schwarz T. [Differential therapy of deep venous thrombosis of the leg veins]. Internist (Berl). 2002 Jan;43(1):36, 39–46. doi: 10.1007/s108-002-8080-9.
      参考文献:10.1007/s10557-011-6301-0
      摘要:Kvasnička J, Horák J, Zenáhlíková Z, Kvasnička T, Simek S, Kovárník T, Malíková I, Linhart A, Aschermann M. Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI. Cardiovasc Drugs Ther. 2011 Jun;25(3):243–50. doi: 10.1007/s10557-011-6301-0.
      参考文献:10.1186/1748-5908-6-48
      摘要:Gattellari M, Leung DY, Ukoumunne OC, Zwar N, Grimshaw J, Worthington JM. Study protocol: the DESPATCH study: Delivering stroke prevention for patients with atrial fibrillation - a cluster randomised controlled trial in primary healthcare. Implementation Science. 2011 May 20;6(1):48. doi: 10.1186/1748-5908-6-48.
      参考文献:10.1007/s11845-017-1569-0
      摘要:Karadağ C, Yoldemir T, Karadağ SD, İnan C, Dolgun ZN, Aslanova L. Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia. Irish Journal of Medical Science. 2017 Feb 07;186(3):707–13. doi: 10.1007/s11845-017-1569-0.
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