CAS: 50-23-7; Cortisol

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CAS号50-03-3 醋酸氢化可的松 | CAS号53-06-5 可的松 | CAS号101524-47-4 17,21-二羟基-孕烯-4-... | CAS号76338-54-0 11,17,21-三羟基-孕烯... | CAS号104117-71-7 21-acetoxy-17-h... | CAS号50-04-4 醋酸可的松 | CAS号102213-14-9 22-acetoxy-11β-... | CAS号64313-94-6 5β-二氢皮质醇21-乙酸盐 | CAS号566-35-8 11-表氢化可的松 | CAS号102030-55-7 11α,17α,21-三羟基-... | CAS号382-45-6 肾上腺甾酮 | CAS号382-44-5 4-雄烯-11β-醇-3,17-二酮 | CAS号1816-85-9 11BETA-羟基睾酮 | CAS号2899-95-8 20-hydroxycortisol | CAS号1719-79-5 20-aLpha-二氢可的松 | CAS号3597-45-3 cortienic acid | CAS号53-06-5 可的松 | CAS号50-22-6 肾上腺酮 | CAS号2398-99-4 9-脱氢睾丸激素

丁酸氢化可的松置于potassium Hydroxide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 1.5H,以60.3 G的收率获得产物氢化可的松
参考文献:一种从丁酸氢化可的松母液中回收氢化可的 松的方法
标题:一种从丁酸氢化可的松母液中回收氢化可的 松的方法
摘要:一种从丁酸氢化可的松母液中回收氢化可的松的方法,包括以下步骤:将丁酸氢化可的松精制母液加入甲醇浓缩至粘稠,然后加入混合溶剂搅拌溶清,降温.在惰性气体的保护下滴加碱液,加毕保温反应.经中和,浓缩,冷冻过滤,烘干得到氢化可的松.本发明通过采用惰性气体保护和混合溶剂相结合的反应方式,有效避免因甾核d环结构断裂所致化合物分解而无法回收物料的情况.本发明方法具有操作简便,处理时间短,生产成本低,生产安全性和物料稳定性高,对环境不会造成污染;回收率高,回收得到的氢化可的松纯度高,干燥后可以直接作为原料生产丁酸氢化可的松.

专利信息

专利号:WO-2009034398-A1
优先权日:2007-09-11
标题:Process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3.17-dione
发明人：HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
权利人:RICHTER GEDEON NYRT; HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
摘要:The invention relates to a novel process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3,17-dione which means dehydrogenating 6-hydroxymethyl-4-androsten- 3,17-dione in the presence of a biocatalyst.

专利号:US-4913852-A
优先权日:1986-06-24
标题 :Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives
发明人：MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
权利人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
摘要:Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Δ-4-pregnene-3,20-dione or with derivatives of Δ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucocorticoidal and anti-inflammatory properties have been prepared and tested. Pharmaceutical compositions, medicaments containing them as well as their applications are claimed, particularly in the cutaneous and ophthalmic fields. ##STR1##

专利号:US-9683007-B2
优先权日:2009-12-18
标 题 :Methods for the purification of deoxycholic acid
发明人：MORIARTY ROBERT M; PRASAD ACHAMPETA RATHAN; REID JOHN GREGORY; SWARINGEN JR ROY A
权利人:KYTHERA BIOPHARMACEUTICALS INC
摘要:Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxysteroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This inversion is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

专利号:US-2025289727-A1
优先权日:2022-05-06
标题 :High entropy oxides and methods of synthesis and use thereof
发明人：RAY TYLER; YIN ZIYU
权利人:UNIV HAWAII
摘要:The present invention provides compositions and nanomaterials comprising a metal based high entropy oxide comprising at least five metals and their oxides distributed in a crystal structure, with high configurational entropy, a high number of oxygen vacancies and active catalytic sites. The present invention also relates to methods of synthesis of said compositions and nanomaterials using microwave irradiation and methods of use of said compositions and nanomaterials in analyte sensing as nanozymes, electrochemical sensors, and colorimetric sensors.

专利号:US-2025305010-A1
优先权日:2022-05-08
标题:Lipid compositions and methods of producing same
发明人：KEREN TOMER; ELLA EZRA; ARGOV-ARGAMAN NURIT
权利人:WILK TECH INTERNATIONAL LTD; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:Provided is a method of increasing lipid synthesis or accumulation in mammary epithelial cells (MECs) culture and optionally secretion therefrom. The method comprising contacting the MECs with an LXR agonist in the presence of a fatty acid to thereby increase lipid synthesis or accumulation and optionally secretion of lipids. Also provided is a method of producing synthetic fat globules, the method comprising: (a) isolating lipid droplets from cells in culture; (b) encapsulating the droplets with a lipid bilayer, thereby producing synthetic fat globules. Also provided are compositions produced thereby.

专利号:WO-0200681-A1
优先权日:2000-06-27
标题 :20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC; PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
摘要:The invention related to 20κ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20κ-fluoro-3β-hydroxypregna-4,17(20)-dien-21-oic acid ethyl ester, 20κ-fluoro-21-hydroxypregna-4,17(20)-dien-3-one, 20κ-fluoropregna-4,17(20)-dien-3β,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5α-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have general formulae (I).