CAS: 484-49-1; 1,5-Dimethyl-6H-Pyrido[4,3-B]Carbazole

上下游产品

5-甲基-6H-吡啶并[4,3-B]咔唑 11-Demethylellipticine 4238-66-8
3-Hydroxyolivacine 2122-23-8
3-Methoxyolivacine 797050-74-9
1-Methyl-9H-Carbazol-3-Carbonitril 97039-93-5
3-甲酰基-1-甲基咔唑 3-Formyl-1-Methylcarbazole 21240-57-3
(1-Methyl-9H-Carbazol-2-yl)Methanol 55854-93-8
2-(1-Methyl-9H-Carbazol-2-yl)Ethan-1-Amine 5531-70-4
2-(1-Methyl-9H-Carbazol-2-yl)Acetonitrile 100880-19-1
1-(1-Methyl-9H-Carbazol-3-yl)-Ethanone 97039-94-6
6-Benzyl-3-Methoxyolivacine 797050-73-8

📜1,5-Dimethyl-4,6-Dihydro-3H-Pyrido[4,3-B]Carbazole置于palladium 10% On Activated Carbon体系中,用 二苯醚 作为反应溶剂,化学反应 0.5H,以55%的收率获得产物1,5-二甲基-6H-吡啶并[4,3-B]咔唑
参考文献:橄榄碱溶酶体胞吐作用解释癌细胞耐药性的方法
标题:橄榄碱溶酶体胞吐作用解释癌细胞耐药性的方法
摘要:Ellipticine 是一种吲哚生物碱,在体外具有针对各种肿瘤的抗肿瘤活性和多种作用机制,包括拓扑异构酶 Ii 抑制,嵌入和细胞周期影响.olivacine(玫瑰树碱的异构体)显示出相似的特性.这项工作的目标如下:(A) 寻找橄榄素合成的新途径,(B) 研究橄榄素和玫瑰树碱与多柔比星相比的细胞毒性及其对细胞周期的影响,以及 (C)) 研究受试化合物的细胞药代动力学,以更好地了解癌细胞的耐药性.srb 和 Mtt 测定法用于研究橄榄碱和玫瑰树碱的体外抗癌活性.这两种化合物对各种细胞系都显示出细胞毒性作用,最显着的是对多柔比星耐药的 Lovo/dx 模型,橄榄霉素的细胞毒性大约是阿霉素的三倍.与玫瑰树碱相比,橄榄碱被证明对癌细胞的效果较差,对正常细胞的细胞毒性也较小.橄榄绿素被证明具有荧光特性.用橄榄素处理的细胞的显微镜观察显示灵敏度的差异取决于细胞系,与正常 Nhdf 细胞相比,A549
DOI:10.3390/ijms23116119

专利信息

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

专利号:WO-2013087821-A1
优先权日:2011-12-15
标题:Overproduction of jasmonates in transgenic plants
发明人：CHAMPION ANTONY
权利人:INST RECH DEVELOPPEMENT IRD
摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-2007172520-A1
优先权日:2005-11-18
标题:Immunotargeting of Nonionic Surfactant Vesicles
发明人：VANAUKER MICHAEL; PLAAS ANNA; HOOD ELIZABETH
权利人:UNIV SOUTH FLORIDA
摘要:An immunoniosmes for targeted delivery of therapeutic agents to specific tissues in a host and methods of synthesis of those niosomes. An antibody molecule having specificity for a target antigen, such as a cell surface marker or other marker differentially expressed on a target cell, is covalently coupled to a functionalized membrane constituent. In a particular embodiment the functionalized membrane constituent is polyoxyethylene sorbitan monostearate functionalized with cyanuric chloride. The niosomes of this invention thus provide a composition that enhances internalization or retention of the bioactive agent of the niosome into the cytoplasm of the cells of the target tissue by providing a high degree of target specificity. Furthermore, the membrane vesicle enhances the life of the therapeutic agent by preventing its degradation in the extracellular environment, while exhibiting lower toxicity than can occur with some liposomes. The niosomes of the present invention are thus particularly useful as vehicles for the delivery of therapeutics to specific target cells.

专利号:US-9371387-B2
优先权日:2011-11-10
标题 :Composition for prevention or treatment of ischemic cardiac disease, comprising inhibitor against age-albumin synthesis or release of mononuclear phagocyte system cells as active ingredient
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:UNIV GACHON IND ACAD COOP FOUND
摘要:Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin-induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction.

专利号:US-2007203079-A1
优先权日:2005-11-21
标题:Methods of using small molecule compounds for neuroprotection
发明人：CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.