CAS: 41003-94-5; Diethyl Isocyanomethylphosphonate

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N-Formylaminomethanphosphonsaeurediethylester diethyl (phthalimidomethyl)phosphonate aminomethylphosphonic acid diethyl ester(Cyclohexylidenmethyl)is°Cyanid (E)-2-Phenylvinyl Is°Cyanide (Z)-2-(3-Indolyl)vinyl Is°Cyanide (E)-2-(3-Indolyl)vinyl Is°Cyanide

📜二乙基(甲酰氨基甲基)膦酸酯置于三乙胺,三氯氧磷体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 异腈甲基磷酸二乙酯
参考文献:1,5-二取代四唑作为 Pd-1/pd-L1 拮抗剂
标题:1,5-二取代四唑作为 Pd-1/pd-L1 拮抗剂
摘要:通过单克隆抗体(例如pembrolizumab (Keytruda))靶向抑制性免疫检查点蛋白 Pd-1/pd-L1 复合物的创新方法,癌症生存和治疗的进展发生了显着的转变.虽然到 2021 年将产生 172 亿美元的收入,但这些发展的真正意义在于它们能够改善癌症患者的治疗效果.尽管单克隆抗体在抑制 Pd-1/pd-L1 信号通路方面已被证明有效,但它们面临着重大挑战,包括有限的响应率,高生产成本,缺乏口服生物利用度以及可能导致免疫相关不良反应的半衰期延长.影响.一种有前途的替代方法涉及使用小分子作为 Pd-1/pd-L1 拮抗剂来刺激 Pd-L1 二聚化.然而,这些分子的确切作用机制仍不完全清楚,这给它们的发展带来了挑战.在此背景下,我们的研究重点是创建基于ugi四唑四组分反应(ut-4Cr)的新型支架,以开发pd-L1的低分子量抑制剂.采用基于结构的方法,我们使用联苯乙烯基异氰化物合成了一系列小化合物,从而发现了
DOI:10.1039/d3Md00746D

专利信息

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-2014296354-A1
优先权日:2013-04-01
标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions
发明人：WANG GUIJUN; MANGUNURU HARI P R
权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND
摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials

专利号:RU-2153491-C2
优先权日:1993-07-09
标 题 :Vitamin d analogs, methods of their synthesis, pharmaceutical composition