CAS: 312-85-6; Sodium Lactate

上下游产品

DL-glyceraldehyde 3-phosphate alpha-D-glucopyranose 13C-C1-glucopyranose13C-C1-glucopyranose LACTIC ACIDmethyl lactate n-propyl lactate ethyl 2-hydroxypropionate isopentyl lactate

丙酮醛置于gold On Carbon,水,氧气,Sodium Hydroxide体系中,60.0 °C,1.0 Mpa 条件下,反应生成 乳酸钠
参考文献:Selective Formation Of Lactate By Oxidation Of 1,2-Propanediol Using Gold Palladium Alloy Supported Nanocrystals
标题:Selective Formation Of Lactate By Oxidation Of 1,2-Propanediol Using Gold Palladium Alloy Supported Nanocrystals
摘要:使用生物可再生资源,例如甘油,这是一种生物柴油制造的副产品,可以提供一种利用更环保技术制造有价值产品的可行方法.特别是,甘油可以被还原为1,2-丙二醇,然后选择性氧化为乳酸,乳酸作为合成生物可降解聚合物的单体具有巨大潜力.我们展示了金-钯合金催化剂在1,2-丙二醇选择性氧化为乳酸方面的高效性.我们对比了两种载体(tio2和碳)以及两种制备方法(湿法浸渍和溶胶固化).将钯添加到金中显著提高了活性,并在使用o2作为氧化剂时保持了对乳酸的高选择性(我们观测到在94%转化率下乳酸选择性为96%).虽然也可以使用过氧化氢,但由于反应条件,观测到活性较低,在这种情况下,添加钯到金中并未显著提高活性.对c3醇的活性比较表明,反应性按顺序降低:甘油 > 1,2-丙二醇 > 1,3-丙二醇 ∼ 1-丙醇 > 2-丙醇.与浸渍法相比,采用溶胶固化制备方法得到的合金催化剂在1,2-丙二醇氧化反应生成乳酸时具有最高的活性;这些活性趋势的来源进行了讨论.
DOI:10.1039/b823285G

专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-2023313255-A1
优先权日:2020-07-15
标题:Massively Parallel Enzymatic Synthesis of Polynucleotides
发明人：HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER
权利人:DNA SCRIPT
摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:WO-2023170258-A1
优先权日:2022-03-11
标 题 :Apparatus for enzymatic synthesis of a plurality of polynucleotides comprising a condensation trap
发明人：MCCUSKER SEAN; HAO GRACE
权利人:DNA SCRIPT
摘要:An apparatus (500) for enzymatic synthesis of a plurality of polynucleotides, the apparatus (500) comprising a chiller (11) with a condensation generating device (8) and a condensation trap (1) comprising a frame with a front surface (2) and an opposing back surface (4) connected by first and second lateral sides (6), wherein the frame houses a U-shaped inner structure that is formed by two opposing inner side surfaces (12) connected by an inner bottom surface (14), wherein the U-shaped inner structure forms a space traversing the frame between the front surface (2) and the back surface (4), the space configured to accommodate a protuberance of the condensation generating device (8), wherein the inner bottom surface (14) comprises a trough (10) configured to collect condensate from the condensation generating device (8), the trough (10) comprising a sloped surface (16) angled downward from a top edge (18) nearest the back surface (4) to a bottom edge (20) nearest the front surface (2), the bottom edge (20) connecting to a first edge (22) of a condensate channel (23), wherein the condensation trap (1) also comprises a plate (24) forming part of the front surface (2) of the frame and forming a vertical wall of the trough along a second edge of the condensate channel (23) across from the first edge (22), wherein the condensate channel (23) slopes downwards, terminating at an aperture (26), wherein the aperture (26) is in fluid communication with a tubing connector (28).

专利号:US-2014255328-A1
优先权日:2013-03-11
标 题:Hydrothermal Synthesis of Zinc Phlogopite
发明人：MCGUIRE MEAGHAN CLARK; BULL IVOR; JOHNSON GEOFFREY MARK
权利人:BASF SE
摘要:This invention relates to a synthetically derived zinc phlogopite platelets, of superior platelet diameter, effect pigments comprising such synthetically derived platelets and methods of forming said substrates. More specifically the disclosure describes an improved hydrothermal synthesis of zinc phlogopite suitable as a platelets for interference pigments, barrier and flame retardant applications.