CAS: 27933-36-4; 3-Bromo-3-Methyl-2-((2-Nitrophenyl)Thio)-3H-Indole

该化合物是一种化学化合物,其结构复杂,包括一个用溴原子取代的无粉核心,一个甲基组和与一个硝基苯组的硫醚联系,该化合物通常具有与无粉衍生物和硝基苯化合物有关的特性,例如由于溴和硝基组的存在,可能具有生物活动和反应性.不育之物因其在各种生物系统中的角色而闻名,并能够参与各种化学反应,包括电子替代.硝基苯组的存在可能会产生额外的电子效应,影响化合物的再活性和溶性.此外,溴原子可以作为进一步进行化学修改的场所.总的来说,由于其独特的结构特征和潜在用途,该化合物可能对医药化学和材料科学感兴趣.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-7169894-B2
    优先权日:2001-11-14
    标题 :Methods and compositions for reverse translation
    发明人:MARTIN MARK T
    权利人:MIRARI BIOSCIENCES INC
    摘要:A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse translation, to the synthesis of the polynucleotide. The usefulness of reverse translation is that it facilitates the amplification of information held in the amino acid sequence (the primary structure) of an unknown protein or peptide. Amplification is useful for, among other things, the identification and/or scientific investigation of the peptide or protein.

    专利号:US-2022389374-A1
    优先权日:2021-05-06
    标题:Use of functionalized and non-functionalized ecms, ecm fragments, peptides and bioactive components to create cell adhesive 3d printed objects
    发明人:KAUR AMAN; HERNANDEZ VICTOR; NSIAH BARBARA; ARIAS ISABEL; ALVAREZ LUIS
    权利人:LUNG BIOTECHNOLOGY PBC
    摘要:Embodiments of this disclosure relate to bioinks and bioink compositions. These bioinks may be 3D printed into a hydrogel. The printed hydrogel may support primary cell and induced pluripotent stem cell attachment, proliferation, and spreading. Compounds in the bioink may be modified to incorporate chemical functionality, such as by chemical synthesis means. Incorporating chemical functionality may allow the incorporation of modified material as a component in the bioink. The modifications may allow chemical conjugation of a desired component. The desired component may maintain its cell interactive feature to aid in cell attachment and proliferation. Such incorporation may allow modulation of the bioprinted object's mechanical properties without interfering with cell adhesion.

    专利号:US-12234299-B2
    优先权日:2018-11-22
    标 题 :Peptides for inducing bacteriocin synthesis and methods to identify and/or select and/or optimize the same
    发明人:MIGNOLET JOHANN; HOLS PASCAL; LEDESMA GARCÃ?A LAURA
    权利人:SYNGULON S A; UNIV CATHOLIQUE LOUVAIN
    摘要:Described herein is a peptide or peptidomimetic with a length of at least 6 residues comprising, consisting essentially of, or consisting of the sequence motif Xaa1-Trp-Xaa2-Xaa3-Xaa4-Xaa5 (SEQ ID NO:1), wherein: Xaa1 represents an aromatic residue (Phe, Tyr, Trp, His), Cys or Ser; Xaa2, Xaa3 and Xaa4 represent any residue; and Xaa5 represents Gly, lie or Val.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

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    [参考文献]: M B Sankaram, Et Al. Interaction Of Two Complementary Fragments Of The Bovine Spinal Cord Myelin Basic Protein With Phospholipid Bilayers. An Esr Spin-Label Study. Biochemistry. 1989 Dec 12;28(25):9692-8.
    [参考文献]: N Swamy, Et Al. Molecular Modeling, Affinity Labeling, And Site-Directed Mutagenesis Define The Key Points Of Interaction Between The Ligand-Binding Domain Of The Vitamin D Nuclear Receptor And 1 Alpha,25-Dihydroxyvitamin D3. Biochemistry. 2000 Oct 10;39(40):12162-71.
    [参考文献]: N Swamy, Et Al. Probing The Vitamin D Sterol-Binding Pocket Of Human Vitamin D-Binding Protein With Bromoacetate Affinity Labeling Reagents Containing The Affinity Probe At C-3, C-6, C-11, And C-19 Positions Of Parent Vitamin D Sterols. Arch Biochem Biophys. 2000 Jan 15;373(2):471-8.
    [参考文献]: N Swamy, Et Al. Roles Of The Structure And Orientation Of Ligands And Ligand Mimics Inside The Ligand-Binding Pocket Of The Vitamin D-Binding Protein. Biochemistry. 1997 Jun 17;36(24):7432-6.

    合成参考文献


    参考文献:10.1007/s11274-013-1368-3
    摘要:Pandey N, Malik RK, Kaushik JK, Singroha G. Gassericin A: a circular bacteriocin produced by Lactic acid bacteria Lactobacillus gasseri. World Journal of Microbiology and Biotechnology. 2013 May 28;29(11):1977–87. doi: 10.1007/s11274-013-1368-3.
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