CAS: 2637-34-5; Pyridine-2(1H)-Thione

相似化合物

18368-58-6 204996-08-7 1199806-26-2

上下游产品

CAS号39161-85-8 2-疏基苯乙酸 | CAS号46721-77-1 phenacyl-(2-pyr... | CAS号2127-03-9 2,2'-二硫二吡啶 | CAS号1121-31-9 2-巯基吡啶 N-氧化物 | CAS号109-04-6 2-溴吡啶 | CAS号61-90-5 L-亮氨酸 | CAS号105678-24-8 O-t-butyl S-(2-... | CAS号147-85-3 脯氨酸 | CAS号73-22-3 L-色氨酸 | CAS号10002-30-9 phenyl-pyridin-... | CAS号111480-82-1 2-PYRIDINESULFO... | CAS号105802-70-8 menthyl 3-(2-py... | CAS号112157-69-4 2-cyclohex-2-en... | CAS号42416-20-6 [2-(Pyridin-2-y... | CAS号146474-88-6 [2-(thiophene-2... | CAS号144365-93-5 2-[(2,2-dimethy... | CAS号4262-06-0 2-吡啶基硫醚 | CAS号18438-38-5 2-甲硫基吡啶 | CAS号174485-72-4 5-三氟甲基吡啶-2-磺酰氯

2-碘吡啶置于sodiumsulfide Nonahydrate,铜,1,2-乙二硫醇体系中,用 二甲基亚砜 用作溶剂,化学反应 20.0H,以76%的收率获得2-巯基吡啶
参考文献:铜催化 1,2-乙二硫醇辅助硫化钠从芳基碘直接合成芳基硫醇
标题:铜催化 1,2-乙二硫醇辅助硫化钠从芳基碘直接合成芳基硫醇
摘要:描述了使用容易获得的 Na2S.9H2O 和 1,2-乙二硫醇从芳基碘化物直接有效地合成芳基硫醇的方法.各种芳基硫醇很容易以 76-99% 的收率获得.在该方案中,Na2S.9H2O 用作最终硫源,1,2-乙二硫醇用作必不可少的催化试剂.
Doi:10.1055/s-0036-1588482

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2023331778-A1
优先权日:2020-08-31
标 题 :An improved process for fmoc synthesis of etelcalcetide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN; CHAVRE PRAFUL SHAMRAO
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of Etelcalcetide and its analogs by solid phase synthesis of Fmoc protected amino acids in a sequential manner, followed by acetylation of terminal D-cys and cleavage of peptide from solid support. The crude heptapeptide thus obtained is reduced using Tris(2-carboxyethyl) phosphine hydrochloride, purified and oxidized with L-cysteine. The oxidized Etelcalcetide is purified and salt exchanged using a one-step reverse phase chromatography process. The purified Etelcalcetide hydrochloride is then precipitated using organic solvents, concentrated and lyophilized to purity of greater than 99.0%.

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.