CAS: 2061-64-5; Ergosterol Peroxide
该化合物是一种有机化合物,主要来源于雌性激素,主要来源于雌性激素,是真菌细胞膜的关键成分;其特征是分子结构,包括一种具有过氧化功能组的类固基;过氧化物以生物活动闻名,表现出抗风,抗菌和潜在的抗癌特性;经常研究其在真菌新陈代谢中的作用及其对人类健康的影响;该化合物通常存在于各种真菌中,并且与蘑菇和酵母等来源隔绝;就物理特性而言,过氧化物一般是白色到黄色固体,在有机溶剂中是可溶的;其稳定性可能受到光和温度等因素的影响,因此在适当条件下处理和储存它以保持其完整性十分重要.
- 英文名称Ergosterol Peroxide
- 中文名称5α,8α-表二氧-(22E,24R)-麦角甾-6,22-二烯-3Β-醇
- IUPAC名称(3S,5S,8S,9R,10R,13R,14R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-1,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol
- 其它别名5a,8a-Ergosta-6,22-dien-3b-ol, 5,8-epidioxy- (7CI,8CI); 5,8-Epidioxy-2H-cyclopenta[a]phenanthrene, ergosta-6,22-dien-3-ol deriv.; (22E)-5a,8a-Epidioxyergosta-6,22-dien-3b-ol; (22E,24R)-5a,8a-Epidioxyergosta-6,22-dien-3b-ol; (24R)-Ergost-5a,8a-epidioxy-6,22-dien-3b-ol; 22E,24R-5a,8a-Epidioxyergosta-6,22-dien-3b-ol; 3b-Hydroxy-5a,8a-epidioxyergosta-6,22-diene; 5,8-Epidioxy-5a,8a-ergosta-6,22-dien-3b-ol; 5,8a-Epidioxy-5a-ergosta-6,22-dien-3b-ol; 5a,8a,-Epodioxy-(22E,24R)-ergosta-6,22-diene-3b-ol; 5a,8a-Epidioxy-(22E,24R)-ergosta-6,22-dien-3b-ol; 5a,8a-Epidioxy-22E-ergosta-6,22-dien-3b-ol; 5a,8a-Epidioxyergosta-6,22-dien-3b-ol; 5a,8a-Epidioxyergosterol; Ergosterol 5,8-peroxide; Ergosterol 5a,8a-epidioxide; Ergosterol endoperoxide; Ergosterolperoxide; Peroxyergosterol
- CAS编号2061-64-5
- MFCD编号:MFCD00201664
- FDA UNII编号:UG9TN81TGH
- 分子式:C28H44O3分子量:428.65
- 产品CID: 1052314
- 产品分类天然产物 → 甾体化合物
物理性质
- 熔点178 °C
- 沸点499.7±45.0 °C(预测)
- 闪点256 °C
- 密度1.08±0.1 g/cm3(预测)
- pKa:14.97±0.70(预测)
- PSA:38.69
- LogP:6.4736
- 蒸汽压4.42E-12 mmHg at 25 °C
- 溶解性Methanol: Soluble
- 外观形态白色至类白色粉末
- 储存条件储存在 -20°C
- 产品应用该化合物是一种氧化性酯剂和衍生物,在S. ASPRATUS中发现,具有多种生物活动,对P.FALCIPARUM 氯丙酮敏感菌株FCA 20/GHA有活性,IC50值为8.2 ΜM.ERGOSTEROL 全氟氧化物在LNCAP和DU145 前列腺癌细胞中诱发了吸食性中毒,抑制SNU-1气管,SNO-354肝瘤和SNUS-C4 直肠癌细胞的生长.EMGOSTEROOL PERTOCOL 抑制LPS 引起的NF-KB DNA结合活动,以及在RAW 26.47细胞中生产TF-Α.4 过氧过氧化剂的原施用在鼠标12米国家13腹腔炎诱发炎模型中减少耳肿,ID50值0.2毫克/EAR的鼠标.
MSDS等安全信息
上下游产品
Ergosterol isopyr°Calcyferyl acetatet-dien-5-ol3β-acetoxy-5α-ergosta-7,22t-dien-5-ol Ergosterol ergosta-4,6,8(14),22-tetraen-3-one合成工艺路线路线简述
- 57-87-4 = 2061-64-5 + 486455-94-1 + 86363-50-0
反应条件:1.1 Reagents: Rose Bengal Solvents: Ethanol
标题:A New Look Into The Reaction Between Ergosterol And Singlet Oxygen In Vitro
作者:Ponce,Maria A.; Et Al
参考文献:Photochemical & Photobiological Sciences 日期:2002 卷标:1(10) 页码:749-756
📜麦角固醇置于亚磷酸三苯酯,臭氧体系中,用 二氯甲烷 用作溶剂,化学反应生成5α,8α-表二氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇
参考文献:海洋海绵raspailia Pumila和模型化合物与空气中氧的甘油的长链乙炔烯醇醚的氧化破坏
标题:海洋海绵raspailia Pumila和模型化合物与空气中氧的甘油的长链乙炔烯醇醚的氧化破坏
摘要:Raspailynes(具有从头到北大西洋海绵raspailia Pumila和r. Ramosa分离的乙炔和烯键的烯醇醚双键序列共轭的甘油的新型长链烯醇醚)在正常水解条件下是稳定的烯醇醚的条件.相反,当它们的溶液蒸发时,这些脂质如雷帕西林bl(=(-))-3-[(1 Z,5 Z)-(十四烷基-1,5-二烯-3-炔基)氧基]-1,2-丙二醇;(-2)在正常实验室日光条件下与空中o 2迅速反应,C = C烯醇醚键断裂,得到1-O-甲酰甘油(3)和醛(例如(-)-2的tridec-4-En-2Ynal(4)).该反应必须由三重态o 2引起,因为热生成的单重态o 2对溶液中的(-)-2没有影响.用模型化合物1-甲氧基戊二烯-1-En-3-Yn-5-Ol(6A)及其5-O证明了仅存在与炔基基团偶联的烯醇醚部分是造成这种现象的原因.-乙酰基或5-O-四-氢吡喃基衍生物6B和6C.耐水解条件和单线态o
Doi:10.1002/hlca.19870700521
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12263177-B2
优先权日:2019-02-07
标题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
发明人：MARTINEZ-MONTEMAYOR MICHELLE M; RIVAS FATIMA
权利人:UNIV CENTRAL DEL CARIBE; ST JUDE CHILDRENS RES HOSPITAL INC
摘要:The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.
专利号:CA-3129092-A1
优先权日:2019-02-07
标题 :Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:WO-2020163626-A1
优先权日:2019-02-07
标 题 :Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:US-2025241930-A1
优先权日:2019-02-07
标 题 :Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:EP-3920948-A1
优先权日:2019-02-07
标题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
专利号:US-2022125805-A1
优先权日:2019-02-07
标 题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zhou B, Liang X, Feng Q, Li J, Pan X, Xie P, Jiang Z, Yang Z. Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling. Eur J Pharmacol. 2019 Oct 5;860:172543. doi: 10.1016/j.ejphar.2019.172543. Epub 2019 Jul 16. 19(2):93-105. doi: 10.1615/IntJMedMushrooms.v19.i2.10. 9(9):484. doi: 10.3390/biom9090484.
4: Ling T, Lang WH, Martinez-Montemayor MM, Rivas F. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229. doi: 10.1039/c9ob00145j.
5: Bu M, Li H, Wang H, Wang J, Lin Y, Ma Y. Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity. Molecules. 2019 Sep 11;24(18):3307. doi: 10.3390/molecules24183307.
合成参考文献
摘要:Bai B, Chen Y, Liu WJ, Yin M, Wang M, Feng X. [Chemical Constituents of Petroleum Ether Fraction of Lonicera macranthoides Roots]. Zhong Yao Cai. 2015 Mar;38(3):518–20.
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