CAS: 1454885-45-0; (1S,5R)-4-((E)-3,4-Dihydroxy-5-Methoxystyryl)-6,6-Dimethylbicyclo[3.1.1]Hept-3-En-2-One

主要参考文献

1: Mander S, Kim DH, Thi Nguyen H, Yong HJ, Pahk K, Kim EY, Lee K, Seong JY, Kim WK, Hwang JI. SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling. Sci Rep. 2019 Apr 29;9(1):6595. doi: 10.1038/s41598-019-41224-y.
2: Pahk K, Noh H, Joung C, Jang M, Song HY, Kim KW, Han K, Hwang JI, Kim S, Kim WK. A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation. J Transl Med. 2019 Aug 20;17(1):274. doi: 10.1186/s12967-019-2024-y.
3: Pahk K, Joung C, Song HY, Kim S, Kim WK. SP-8356, a Novel Inhibitor of CD147-Cyclophilin A Interactions, Reduces Plaque Progression and Stabilizes Vulnerable Plaques in apoE-Deficient Mice. Int J Mol Sci. 2019 Dec 21;21(1):95. doi: 10.3390/ijms21010095.

合成参考文献

参考文献:10.1016/j.bmcl.2013.07.038
摘要:Ju C, Song S, Hwang S, Kim C, Kim M, Gu J, Oh YK, Lee K, Kwon J, Lee K, Kim WK, Choi Y. Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects. Bioorg Med Chem Lett. 2013 Oct 01;23(19):5421–5. doi: 10.1016/j.bmcl.2013.07.038.