CAS: 13958-93-5; 3,5-Dichloroisonicotinic Acid

相似化合物

136590-83-5 153463-65-1 88912-27-0

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CAS号124-38-9 二氧化碳 | CAS号2457-47-8 3,5-二氯吡啶 | CAS号75-09-2 二氯甲烷 | CAS号55-22-1 异烟酸 | CAS号42935-09-1 2,3,5,6-四氯异烟酰氯 | CAS号7719-09-7 氧氯化硫 | CAS号264123-70-8 3,5-二氯-4-氯甲基-吡啶 | CAS号2457-47-8 3,5-二氯吡啶 | CAS号70593-51-0 3,5-二氯-4-吡啶-羧酰胺 | CAS号544703-97-1 3,5-dichloro-1-...

3,5-二氯吡啶置于co2,二异丙胺体系中,用 四氢呋喃,Tif 用作溶剂,化学反应生成3,5-二氯吡啶-4-羧酸
参考文献:N-Arylsulfonyl Aryl Aza-Bicyclic Derivatives As Potent Cell Adhesion Inhibitors
标题:N-Arylsulfonyl Aryl Aza-Bicyclic Derivatives As Potent Cell Adhesion Inhibitors
摘要:化合物i的拮抗剂是vla-4和/或alpha4/beta7,因此在抑制或预防细胞粘附和细胞粘附介导的病理过程中是有用的.这些化合物可以制成药物组合物,适用于治疗艾滋病相关痴呆,过敏性结膜炎,过敏性鼻炎,阿尔茨海默病,哮喘,动脉粥样硬化,自体骨髓移植,某些类型的毒性和免疫性肾炎,接触性皮肤过敏,炎症性肠病包括溃疡性结肠炎和克罗恩病,炎症性肺部疾病,病毒感染的炎症后遗症,脑膜炎,多发性硬化症,多发性骨髓瘤,心肌炎,器官移植,银屑病,肺纤维化,再狭窄,视网膜炎,类风湿性关节炎,脓毒性关节炎,中风,肿瘤转移,葡萄膜炎和i型糖尿病.

专利信息

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-6444820-B1
优先权日:1995-04-07
标题:Process for the manufacture of camptothecin derivatives
发明人：HENEGAR KEVIN E; SIH JOHN C
摘要:This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as a novel method of making mappicine.

专利号:WO-2010126607-A2
优先权日:2009-04-30
标 题:Synthesis of tetracyclines and intermediates thereto

专利号:US-2016002183-A1
优先权日:2009-04-30
标 题:Synthesis of tetracyclines and intermediates thereto

专利号:US-2012115818-A1
优先权日:2009-04-30
标题:Synthesis of tetracyclines and intermediates thereto

专利号:EP-2424834-A2
优先权日:2009-04-30
标题:Synthesis of tetracyclines and intermediates thereto