CAS: 1246525-60-9; N-(4-(1,1,1,3,3,3-Hexafluoro-2-Hydroxypropan-2-yl)Phenyl)-4-(Trifluoromethyl)Benzamide

上下游产品

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 4-trifluoromethyl-phenyl acetyl chloride

📜2-(4-氨基苯)-1,1,1,3,3,3-六氟-2-丙醇,4-三氟甲基苯甲酰氯置于n,N-二异丙基乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 8.0H,以71%的收率获得sr 1078; N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-4-(三氟甲基)苯甲酰胺
参考文献: Modulators Of The Retinoic Acid Receptor-Related Orphan Receptors[fr] Modulateurs Des Récepteurs Orphelins Liés Au Récepteur De L'Acide Rétinoïque
标题: Modulators Of The Retinoic Acid Receptor-Related Orphan Receptors[fr] Modulateurs Des Récepteurs Orphelins Liés Au Récepteur De L'Acide Rétinoïque
摘要:这项发明提供了调节视黄酸受体相关孤儿受体的小分子调节剂,如rorα,Rorβ或rorγ.该发明的化合物可以在无法对lxr受体或其他核受体或其他生物靶点产生作用的浓度下起到有效的调节作用.还提供了调节rors的方法以及治疗代谢紊乱,免疫紊乱,癌症和中枢神经系统紊乱的方法,其中调节ror在医学上是指示的.

专利信息

专利号:US-2025305010-A1
优先权日:2022-05-08
标题:Lipid compositions and methods of producing same
发明人：KEREN TOMER; ELLA EZRA; ARGOV-ARGAMAN NURIT
权利人:WILK TECH INTERNATIONAL LTD; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:Provided is a method of increasing lipid synthesis or accumulation in mammary epithelial cells (MECs) culture and optionally secretion therefrom. The method comprising contacting the MECs with an LXR agonist in the presence of a fatty acid to thereby increase lipid synthesis or accumulation and optionally secretion of lipids. Also provided is a method of producing synthetic fat globules, the method comprising: (a) isolating lipid droplets from cells in culture; (b) encapsulating the droplets with a lipid bilayer, thereby producing synthetic fat globules. Also provided are compositions produced thereby.

专利号:WO-2023241717-A1
优先权日:2022-06-16
标题:Substance for promoting regeneration and repair of organs of mammals and use thereof
发明人：LI WEI; ZHOU QI; He zheng-quan; LU ZONGBAO; WANG SHUAI; WANG XIN; YUAN XUEWEI; WANG LIU
权利人:INST ZOOLOGY CAS; BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE
摘要:Provided is use of a substance capable of up-regulating ISG gene expression in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The substance for up-regulating ISG gene expression is selected from one or two or more of an MAPK inhibitor, a retinoic acid receptor-related orphan receptor inhibitor, a protein synthesis inhibitor, and an interferon (IFNγ, β, λ) or alarmin (S100A8/A9) protein. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.