CAS: 1205-88-5; Glycine P-Nitroanilide

相似化合物

2137859-12-0 104-04-1 17329-87-2

上下游产品

CAS号17329-87-2 2-氯-N-(4-硝基苯基)乙酰胺 | CAS号100-01-6 对硝基苯胺 | CAS号100-01-6 对硝基苯胺 | CAS号56-40-6 甘氨酸

📜Nα-Benzyloxycarbonyl-L-Glycyl-P-Nitroanilide置于氢溴酸体系中,用 溶剂黄146 用作溶剂,化学反应生成甘氨酸对硝基苯胺
参考文献:Synthesis Of Chromogenic Substrates Specific For Human Spleen Fibrinolytic Proteinase (Sfp) And Human Leukocyte Elastase (Le).
标题:Synthesis Of Chromogenic Substrates Specific For Human Spleen Fibrinolytic Proteinase (Sfp) And Human Leukocyte Elastase (Le).
摘要:通过常规方法合成了多种肽苯胺,目的是获得人类脾纤维蛋白溶解酶(sfp)和人类白细胞弹性蛋白酶(le)的特定底物,以便比较sfp和le的底物特异性.研究发现,琥珀酰三肽对硝基苯胺(suc-Tyr-Leu-X-Pna)中的p1 Val化合物在sfp和le的水解反应中表现出最高的kcat/km值,然而,四肽suc-Ala-Tyr-Leu-Val-Pna(sfp和le的水解反应的kcat/km值(m-1S-1):分别为84000和48000)是sfp和le的首选显色底物,因为它具有在缓冲液中的高溶解性和适中的kcat/km值.发现sfp的底物特异性与le的相似.
Doi:10.1248/cpb.30.4060

专利信息

专利号:US-2009215986-A1
优先权日:2006-03-08
标题:Solution Synthesis of Peptide Cell Growth Stimulators
发明人：EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
权利人:EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
摘要:A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale.

专利号:US-2007213505-A1
优先权日:2006-03-08
标 题 :Solution Synthesis of Peptide Cell Growth Stimulators