CAS: 1192-30-9; 2-(Bromomethyl)Tetrahydrofuran

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CAS号97-99-4 四氢糠醇 | CAS号821-09-0 4-戊烯-1-醇 | CAS号882-33-7 二苯二硫醚 | CAS号67-56-1 甲醇 | CAS号799790-05-9 1,5-dimethoxy-p... | CAS号59287-66-0 4,5-dibromo-pen... | CAS号10035-10-6 氢溴酸 | CAS号100606-66-4 1,5-dibromo-pen... | CAS号123-91-1 1,4-二氧六环 | CAS号60-29-7 乙醚 | CAS号33414-62-9 2-(四氢呋喃-2-基)乙腈 | CAS号21614-98-2 (3E,5E)-6-pheny... | CAS号1830-47-3 4-methylhex-3-e... | CAS号1906-96-3 2-(4-戊烯)丙二酸二乙酯 | CAS号2429-96-1 Furan,tetrahydr... | CAS号821-09-0 4-戊烯-1-醇 | CAS号96-47-9 2-甲基四氢呋喃 | CAS号2434-00-6 四氢呋喃-2-乙酸 | CAS号38401-84-2 2-乙基-1,6-二噁螺[4.4]-壬烷 | CAS号1003-17-4 2,2-二甲基四氢呋喃

四氢糠醇 反应生成2-溴甲基四氢呋喃
参考文献:[3 + 2]双环[ M .3.0]烷基烷烃-3-On-2-基-1-氧鎓鎓盐的环还原成烯基氧乙烯酮.立体定向方面
标题:[3 + 2]双环[ M .3.0]烷基烷烃-3-On-2-基-1-氧鎓鎓盐的环还原成烯基氧乙烯酮.立体定向方面
摘要:铑(II)催化的带有环醚部分的重氮酮1的分子内反应瞬时形成双环[ M .3.0] octan-3-One-1-Oxonium-2-Ylides(2),其经历了σ和立体定向性[3 + 2 ]环还原反应,形成烯基氧乙烯酮3.乙烯酮被甲醇有效地捕集,形成相应的酯4.机理研究表明,醚环的大小至少可在thf至thp,氧杂环丁烷和氧杂环丁烷部分范围内变化,即m= 3-6.另一方面,含有羰基单元的ylide环的尺寸被限制为五元环.如通过在键裂解位置带有甲基的非对映异构体对的反应所证明的,发现环还原是立体特异性的.从苏式异构体7中,仅形成(e)-烯基氧乙酸酯15(77-84%),而从赤型异构体8中,形成(z)-异构体16形成了(80-88%).在使用杂化密度泛函b3Lyp和高度相关的二次构型相互作用qcisd方法进行计算的基础上,分析了重氮丙酮取代的环醚经双环氧鎓烷基化物裂解为链烯基氧乙烯酮的机理,揭示了协同的[3
Doi:10.1021/jo0301806

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2002045747-A1
优先权日:1996-12-23
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds