CAS: 111662-65-8; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-5-(Tert-Butoxy)-4-(Tert-Butoxycarbonyl)-5-Oxopentanoic Acid
该化合物是合成与生物相关的和蛋白质的关键试剂,它提供高纯度和高稳定性,促进高效固相酸合成,其保护的氨基酸结构可以使防腐和改性变,确保药用化学和药物发现中的多种用途.
- 英文名称(R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-5-(Tert-Butoxy)-4-(Tert-Butoxycarbonyl)-5-Oxopentanoic Acid
- 中文名称(R)-2-(((((9H-芴-9-基)甲氧基)羰基)氨基)-5-(叔丁氧基)-4-(叔丁氧基羰基)-5-氧代戊酸
- IUPAC名称(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-4-(tert-butoxycarbonyl)-5-oxopentanoic acid
- 其它别名N-(9-芴甲氧羰基)-Gamma-羧基-D-谷氨酸 Gamma-二叔丁酯; Fmoc-D-Gla(Otbu)2-Oh
- CAS编号111662-65-8
- MFCD编号:MFCD00672341
- 分子式:C29H35NO8分子量:525.59
- 产品CID: 151720
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
104091-08-9 71989-18-9 204251-24-1物理性质
MSDS等安全信息
上下游产品
γ,γ'-di-tert-butyl-L-γ-carboxyglutamic acid N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (fluorenylmethoxy)carbonyl chloride 2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2008031812-A1
优先权日:1999-06-02
标 题:Redox-stable, non-phosphorylated cyclic peptide inhibitors of sh2 domain binding to target protein, conjugates, thereof, compositions and methods of synthesis and use
发明人：ROLLER PETER P; LONG YA-QIU; LUNG FENG-DI T; KING C RICHTER; YANG DAJUN; VOIGT JOHANNES H
权利人:GOVERNMENT OF THE USA REPRESEN; UNIV GEORGETOWN
摘要:A compound of formula: n n nin which (i) aa 1 is Adi and aa 4 is Glu or (ii) each of aa 1 and aa 4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC 50 in vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.
专利号:US-2006014927-A1
优先权日:1999-06-02
标题:Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
专利号:US-2003078368-A1
优先权日:1999-06-02
标题 :Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
专利号:US-6951915-B2
优先权日:1999-06-02
标 题:Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1016/j.tetlet.2005.10.121
📝 需求与反馈
尽可能描述清楚需求与问题信息
