CAS: 11018-89-6; 3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-Tetrahydroxy-10-(Hydroxymethyl)-13-Methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxy-2,3,4,6,7,8,9,11,12,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-17-Yl]-2H-Furan-5-One;Octahydrate

📜2-乙酰氨基-3,4,6-三-O-乙酰-2-脱氧-α-D-吡喃葡萄糖酰基氯置于sodium Methylate,三乙胺体系中,用 甲醇,乙腈 用作溶剂,化学反应 16.5H,反应生成毒毛旋花苷g
参考文献:Glycosides Having Chromophores As Substrates For Sensitive Enzyme Analysis. Iv. Synthesis Of N-Acetyl-.Beta.-D-Glucosaminides Of Fluorescein Derivatives And Their Application To The Rate-Assay Of N-Acetyl-.Beta.-D-Glucosaminidase.
标题:Glycosides Having Chromophores As Substrates For Sensitive Enzyme Analysis. Iv. Synthesis Of N-Acetyl-.Beta.-D-Glucosaminides Of Fluorescein Derivatives And Their Application To The Rate-Assay Of N-Acetyl-.Beta.-D-Glucosaminidase.
摘要:通过引入 N-乙酰基-β-D-氨基葡萄糖苷,合成了三种新型 N-乙酰基-β-D-氨基葡萄糖苷,即 2',7'-二氯荧光素单(N-乙酰基-β-D-氨基葡萄糖苷)(6A),荧光素单(N-乙酰基-β-D-氨基葡萄糖苷)(6B)和 2',7'-Dichlorofluorescein Di(N-Acetyl-β-D-Glucosaminide) (7A)是通过在荧光素衍生物中引入 N-Acetyl-β-D-Glucosaminyl 基团,然后去除保护基团而合成的.化合物 6A,6B 和 7A 经 N-乙酰基-β-D-葡糖胺苷酶水解后,在弱酸性速率测定条件(ph 值为 5.0)下,产物在长吸收波长(500,465 和 485 纳米)处显示出较高的吸光度.6A 和 7A 的 Km 值分别为 0.56 和 0.86 Mm.在这些化合物中,7A 被认为是最有可能用于 N-乙酰基-β-D-葡糖胺酶速率测定的发色底物,因为它在酶水解作用下会产生从无色到橙色的明显颜色变化(λmax 280->485 Nm),并且具有超过 30 Mm 的较高水溶性.
Doi:10.1248/cpb.41.314

专利信息

专利号:US-6362009-B1
优先权日:1997-11-21
标 题 :Solid phase synthesis of heterocycles
发明人：MUNOZ BENITO; CHEN CHIXU
权利人:MERCK & CO INC
摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

专利号:EP-0658564-B1
优先权日:1986-04-30
标题 :Electroluminescent compounds and intermediates in their synthesis
发明人：MASSEY RICHARD J; POWELL MICHAEL J; MIED PAUL A; POONIAN MOHINDAR S; FENG PETER; CIANA LEOPOLDO DELLA; DRESSICK WALTER J
权利人:IGEN INT INC
摘要:Novel compounds for use in electrochemiluminescent assays and characterised by containing the structure        X - Y - ZwhereinX represents one or more nucleotides which may be the same or different, one or more amino acids which may be the same or different, an antibody, an analyte of interest or an analogue of an analyte of interestY represents a linker group attached to X and Z,andZ represents an electrochemiluminescent moiety, and intermediates employed in their synthesis.

专利号:US-5380847-A
优先权日:1992-10-22
标 题 :Synthesis of certain 1-(1-methylpiperidin-4-y1)-3-phenylpyrazolo[4,3-C]pyridines

专利号:US-2018230127-A1
优先权日:2015-08-13
标题 :Bicyclic-Fused Heteroaryl Or Aryl Compounds
发明人：ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; GAVRIN LORI KRIM; GOLDBERG JOEL ADAM; LEE ARTHUR; LOWE MICHAEL DENNIS; PATNY AKSHAY; PIERCE BETSY SUSAN; SAIAH EDDINE; TRZUPEK JOHN DAVID
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

专利号:RU-2075479-C1
优先权日:1991-02-04
标 题 :Arylhydroxyalkylheteroaryl-8-azabicyclo[3,2,1]octanes, method of their synthesis and heteroaryl-8-azabicyclo[3,2,1]octanes