CAS: 1098-97-1; 5,5'-(Disulfanediylbis(Methylene))Bis(4-(Hydroxymethyl)-2-Methylpyridin-3-Ol)

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欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

pyrithioxin dihydr°Chloride

合成工艺路线路线简述

    📜Pyrithioxin Dihydrochloride置于sodium Carbonate体系中,用 水 用作溶剂,以70%的收率获得吡硫醇
    参考文献:二芳香基亚甲基二硫醚类化合物及其制备方 法与应用
    标题:二芳香基亚甲基二硫醚类化合物及其制备方 法与应用
    摘要:本发明涉及药物技术领域,尤其涉及二芳香基亚甲基二硫醚类化合物及其制备方法与应用.实验结果,本发明提供的二芳香基亚甲基二硫醚类化合物,在细胞模型上具有抑制过量谷氨酸导致的神经毒性的作用和抑制过氧化氢导致的神经毒性的作用;还具有抗血小板聚集的作用,在小鼠mcao模型中能减少脑梗死面积的作用.这些结果表明本发明提供的这类二芳香基亚甲基二硫醚类化合物可针对脑卒中具有预防和/或治疗的作用.

    海关参考信息

    专利信息


    专利号:US-7300639-B2
    优先权日:2002-12-03
    标 题:Process for removing metals from liquids
    发明人:LIU WANSHENG
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

    专利号:US-12036300-B2
    优先权日:2021-03-31
    标题:Methods and compositions for improving skin
    发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
    权利人:OREAL
    摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

    专利号:WO-0074705-A1
    优先权日:1999-06-08
    标 题 :Rheumatic autoimmune disease antigen
    发明人:PREHM PETER
    权利人:PREHM PETER
    摘要:The invention relates to the utilization of reaction products as antigens for the diagnosis and therapy of rheumatic autoimmune diseases, especially rheumatic arthritis. Said reaction products are obtained by reacting proteins and/or peptides with reactive substances that react under physiological conditions with functional protein and/or peptide groups by forming covalent bonds, whereby the reaction products are recognized by the antibodies of patients suffering from rheumatic autoimmune diseases. The invention also relates to the utilization and synthesis of bis[aminothiols], bis-hydrazine derivatives or bis-amine derivatives as therapeutic agents for diseases caused by dicarbonyl; especially rheumatic arthritis.

    专利号:CN-107602460-A
    优先权日:2017-08-30
    标题 :Synthesis of zinc pyrithione sulfate by adding 2‑mercaptopyridine nitrogen oxide with ZnO

    专利号:CN-112358501-A
    优先权日:2020-11-20
    标 题:A kind of green synthesis method of methyl pyrimidine phosphorus

    专利号:CN-119264041-A
    优先权日:2024-10-05
    标题 :Synthesis process of pyritinol hydrochloride

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Alkuraishy HM, Al-Gareeb AI, Albuhadilly AK. Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study. Biomed Res Int. 2014;2014:324307. doi: 10.1155/2014/324307. Epub 2014 Dec 7.
    2: Jebasingh D, Devavaram Jackson D, Venkataraman S, Adeghate E, Starling Emerald B. The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury. Pharm Biol. 2014 Dec;52(12):1558-69. doi: 10.3109/13880209.2014.908395. Epub 2014 Jul 15. doi: 10.1016/j.ejphar.2008.06.050. Epub 2008 Jun 18.

    合成参考文献


    摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 13(77), 1971
    摘要:Gavrilova SI, Zharikov GA. [Current strategies of pathogenetic therapy of Alzheimer's disease]. Vestn Ross Akad Med Nauk. 2001;(7):13–8.
    参考文献:10.1007/s11055-010-9263-y
    摘要:Chutko LS, Yur’eva RG, Surushkina SY, Nikishena IS, Yakovenko IS, Anisimova TI, Aitbekov KA. Principles of Medical Care for Children with Attention Deficit Hyperactivity Disorder. Neuroscience and Behavioral Physiology. 2010 Feb 13;40(3):351–5. doi: 10.1007/s11055-010-9263-y.
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