专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:EP-1306084-B1 优先权日:1998-06-09 标 题 :Compositions for the control of parasitic infestations in fish 发明人:ALEXANDER SVEIN; EVENSEN OYSTEIN; SYVERTSEN CHRISTIAN; MARTINSEN BERNT 权利人:PHARMAQ AS 摘要:Injectable compositions comprising antiparasitically active chitin synthesis inhibitor substances are described, for controlling parasitic infestations including infestations with sea lice and isopod species in farmed fish. The compositions are optionally formulated in a fish vaccine. The antiparasitically active chitin synthesis inhibitor substances protect the fish against parasites for a substantial period of time after injection. Useful embodiments include compositions with lufenuron that confer protection against new parasitic infestation for an extended period of time after treatment.
专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
专利号:WO-2021074309-A1 优先权日:2019-10-16 标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)
专利号:WO-2021074311-A1 优先权日:2019-10-16 标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)
专利号:US-11369113-B2 优先权日:2017-10-27 标题:Vector control compositions, methods and products utilizing same 发明人:HUETER OTTMAR FRANZ; HOPPE MARK; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; FEDOU NICOLAS; GODINEAU EDOUARD; WEGE PHILIP; MAIENFISCH PETER 权利人:SYNGENTA PARTICIPATIONS AG 摘要:The present inventions concerns use of a specific methoxyacrylate compound to control mosquitoes, and vector control products comprising that methoxyacrylate compound, in particular the invention relates to a substrate, to a composition, for controlling mosquitoes, and to a specific methoxyacrylate compound, processes for the synthesis of mosquitocidal methoxyacrylate compounds and new intermediates.
1: Morel N, Signorini ML, Mangold AJ, Guglielmone AA, Nava S. Strategic control of Rhipicephalus (Boophilus) microplus infestation on beef cattle grazed in Panicum maximum grasses in a subtropical semi-arid region of Argentina. Prev Vet Med. 2017 Sep 1;144:179-183. doi: 10.1016/j.prevetmed.2017.06.006. Epub 2017 Jun 15. doi: 10.1016/j.parint.2017.05.005. Epub 2017 May 17. doi: 10.1016/j.parint.2017.04.006. Epub 2017 Apr 20. doi: 10.1016/j.chemosphere.2017.01.069. Epub 2017 Jan 12. doi: 10.1016/j.prevetmed.2016.10.019. Epub 2016 Nov 3. doi: 10.1111/cbdd.12872. Epub 2016 Nov 2. doi: 10.1590/S1984-29612016006. Epub 2016 Mar 11. doi: 10.1093/jme/tjv129. Epub 2015 Aug 19. doi: 10.1016/j.exppara.2015.02.004. Epub 2015 Feb 26. doi: 10.1016/j.vetpar.2015.01.015. Epub 2015 Jan 28. doi: 10.1016/j.rvsc.2014.04.012. Epub 2014 May 5. doi: 10.1016/j.vetpar.2014.01.012. Epub 2014 Jan 29. doi: 10.1016/j.actatropica.2014.01.008. Epub 2014 Feb 4. doi: 10.1016/j.foodchem.2013.08.027. Epub 2013 Aug 14. doi: 10.1002/jemt.22282. Epub 2013 Sep 2. doi: 10.1007/s00436-013-3282-x. doi: 10.1007/s00436-012-3103-7. Epub 2012 Sep 20. doi: 10.1016/j.exppara.2012.02.023. Epub 2012 Mar 21. doi: 10.1186/1756-3305-5-40. 20: Davis RM, Cleugh E, Smith RT, Fritz CL. Use of a chitin synthesis inhibitor to control fleas on wild rodents important in the maintenance of plague, Yersinia pestis, in California. J Vector Ecol. 2008 Dec;33(2):278-84.
合成参考文献
参考文献:10.1007/s00436-021-07235-3 摘要:Hüe T, Berger A, Wang HH, Grant WE, Teel PD, de León AAP. Integrated control of the cattle tick, Rhipicephalus australis (Acari: Ixodidae), in New Caledonia through the Pasture and Cattle Management method. Parasitol Res. 2021 Aug;120(8):2749–58. doi: 10.1007/s00436-021-07235-3.