CAS: 72093-03-9; 3-Chloro-2-Methylpyridine

相似化合物

72093-07-3 96439-98-4 1881320-96-2

上下游产品

CAS号2402-77-9 2,3-二氯吡啶 | CAS号75-16-1 甲基溴化镁 | CAS号626-60-8 3-氯吡啶 | CAS号3512-76-3 3-chloro-2,6-di... | CAS号137778-09-7 (5-氯-6-甲基-2-吡啶基)甲醇 | CAS号137778-17-7 5-氯-6-甲基吡啶甲醛 | CAS号137778-19-9 5-chloro-6-meth... | CAS号60588-81-0 3-氯吡啶-2-甲醇 | CAS号206181-90-0 3-氯吡啶-2-甲醛 | CAS号57266-69-0 3-氯-2-吡啶甲酸

📜(5-氯-6-甲基-2-吡啶基)甲醇置于selenium(Iv) Oxide,硝酸体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应 4.5H,反应生成 3-氯-2-甲基吡啶
参考文献:Ban-Oganowska,Hanna; Talik,Tadeusz,Polish Journal Of Chemistry,1991,Vol. 65,# 2-3,P. 289-295
标题:Ban-Oganowska,Hanna; Talik,Tadeusz,Polish Journal Of Chemistry,1991,Vol. 65,# 2-3,P. 289-295

专利信息

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:WO-2016071243-A1
优先权日:2014-11-05
标 题:Process for preparing halogenated alkenone ethers and their use in the synthesis of anthranilamide pesticides
发明人：BENSON STEFAN; ZIERKE THOMAS; GOETZ ROLAND; WALK BERNHARD; DOMRES MONIKA
权利人:BASF SE
摘要:The present invention relates to a process for preparing a compound of formula (III) starting from the vinyl ether (IlIa) and the compound (IIIb) with a reagent (lllc) selected from the group of sulfonylhalides or sulfonylanhydrides, e.g. methanesulfonyl chloride or p-toluenesulfonyl chloride, in the presence of a base. The present invention relates also to processes comprising further preceding and/or subsequent reaction steps, leading to anthranilamide pesticides or to precursors for them.

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2014057877-A1
优先权日:2002-12-18
标题:Therapeutic polyamine compositions and their synthesis
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
权利人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-8853410-B2
优先权日:2009-04-30
标 题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.