CAS: 65783-10-0; 1-(3,4-Dichlorophenyl)Guanidine

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    CAS号19250-09-0 3,4-二氯苯基硫脲 | CAS号141407-20-7 1-(3,4-dichloro...

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      📜1-(3,4-Dichlorophenyl)-2-Methylisothiourea Hydroiodide置于ammonium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 12.0H,以90%的收率获得产物n-(3,4-二氯苯基)胍
      参考文献:咪唑烷二酮衍生物的明确合成和预防性抗疟活性.
      标题:咪唑烷二酮衍生物的明确合成和预防性抗疟活性.
      摘要:Wr182393是一种通过肌内注射具有有效的因果预防性抗疟疾活性的胍基咪唑烷二酮衍生物,以前是通过处理氯丙胍和草酸二乙酯制备的,产生两种密切相关的异构体的混合物.混合物的溶解性差使得不可能进行分离和纯化.为了克服分离问题,报道了两种活性成分的新的和容易的明确合成.新的合成方法不仅促进了活性成分的合成,还促进了其衍生物的合成.为了寻找具有非常好口服功效的化合物,通过该新方法制备了一系列活性成分的氨基甲酸酯衍生物,其中许多通过口服显示对小鼠约氏疟原虫具有深远的因果预防性抗疟活性.
      DOI:10.1021/jm0504252

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      专利号:WO-2012149093-A1
      优先权日:2011-04-26
      标 题 :2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof
      发明人：LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
      权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF ARMY; LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
      摘要:The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

      专利号:WO-2012149097-A2
      优先权日:2011-04-26
      标 题 :Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof

      专利号:CN-106380598-A
      优先权日:2016-10-15
      标 题 :A kind of synthesis method and application of polymer ionic liquid

      专利号:CN-106380598-B
      优先权日:2016-10-15
      标 题 :A kind of synthesis method and application of polymer ionic liquid

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      主要参考文献

      参考标题:The Synthesis Of 3,5-Diamino-1,2,4-Oxadiazoles. 2Nd Communication
      作者:Jefferson W. Tilley,Henri Ramuz,Paul Levitan,John F. Blount |发布日期:1980.6.6
      摘要:The 5-Amino-3-Arylamino-1,2,4-Oxadiazoles 2 Are Conveniently Prepared By Oxidative Cyclization Of The Arylamidinoureas 10. The Process Is Also Capable Of Producing A Variety Of The 5-Substituted-Amino Analogs 32 When The Appropriately Substituted Guanidine 31 Is Employed As The Substrate. Two Different Types Of Rearrangement Leading To Triazol-3-Ones Accompany Cyclization Depending On The Choice Of

      合成参考文献


      参考文献:10.1016/s0960-894x(01)00291-8
      摘要:Dukat M, Choi YN, Teitler M, Du Pre A, Herrick-Davis K, Smith C, Glennon RA. The binding of arylguanidines at 5-HT(3) serotonin receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1599–603. doi: 10.1016/s0960-894x(01)00291-8.
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