CAS: 652148-92-0; 2-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyridine

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652148-90-8 2096998-30-8 652148-93-1

上下游产品

CAS号76-09-5 频哪醇 | CAS号5140-72-7 2-溴-6-氯吡啶 | CAS号626-05-1 2,6-二溴吡啶

📜2,6-二溴吡啶置于正丁基锂体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 6-氯吡啶-2-硼酸频哪酯
参考文献:新型卤代吡啶基硼酸和酯的合成.第4部分:卤代吡啶-2-基硼酸和酯是稳定的晶体伴侣,可用于经典的铃木交叉偶联
标题:新型卤代吡啶基硼酸和酯的合成.第4部分:卤代吡啶-2-基硼酸和酯是稳定的晶体伴侣,可用于经典的铃木交叉偶联
摘要:本文描述了用于合成一些方法和新颖的5或6-卤代吡啶-2-基-硼酸和酯隔离3,4,7.这些化合物是通过使用正丁基锂进行区域选择性的卤素-金属交换并随后从适当的二卤代吡啶开始用三异丙基硼酸酯淬灭来制备的.迄今为止研究的所有底物均提供单一的区域异构硼酸或酯产物.另外,已经发现这些化合物与芳基卤化物经历了pd催化的偶联,并授权了一种制备新吡啶库的策略.
DOI:10.1016/j.Tet.2003.10.020

专利信息

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D†). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.