CAS: 62802-38-4; 5-Bromo-2-Fluoropyrimidine

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上下游产品

CAS号14001-72-0 5-溴-2-叔丁基氨基嘧啶

5-溴-2-羟基嘧啶置于n,N'-1,3-Bis(2,6-Diisopropylphenyl)-4,5-Dihydro-2,2-Difluoroimidazolidine,Cesium Fluoride体系中,用 甲苯 作为反应溶剂,化学反应 24.5H,以32%的收率获得产物5-溴-2-氟嘧啶
参考文献:Phenofluor: Practical Synthesis,New Formulation,And Deoxyfluorination Of Heteroaromatics
标题:Phenofluor: Practical Synthesis,New Formulation,And Deoxyfluorination Of Heteroaromatics
摘要:We Report A Practical Synthesis Method Of The Reagent Phenofluor On Decagram Scale,Provide A New Formulation Of Phenofluor As A Toluene Solution,Which Should Decrease Challenges Associated With The Moisture Sensitivity Of The Reagent,And Expand The Substrate Scope Of Deoxyfluorination With Phenofluor To Heteroaromatics.
DOI:10.1021/op500121W

专利信息

专利号:WO-2024064745-A1
优先权日:2022-09-21
标 题:Synthesis of reldesemtiv
发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
权利人:CYTOKINETICS INC
摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.