专利号:WO-2012114280-A1 优先权日:2011-02-23 标 题 :An improved process for the preparation of pyrrolidine thiol derivatives useful in the synthesis of carbapenem compounds 发明人:UDAYAMPALAYAM PALANISAMY SENTHILKUMAR; KANAGARAJ SURESHKUMAR; DASARI VINOD BABU 权利人:ORCHID CHEMICALS & PHARM LTD; UDAYAMPALAYAM PALANISAMY SENTHILKUMAR; KANAGARAJ SURESHKUMAR; DASARI VINOD BABU 摘要:The present invention relates to an improved process for the preparation of the compound of formula (III) which is used in the synthesis of carbapenem antibiotics. wherein R 3 is hydrogen or an amine protecting group.
专利号:US-6180830-B1 优先权日:1995-11-08 标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes 发明人:JACQUOT ROLAND 权利人:RHODIA CHIMIE SA 摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.
专利号:US-11623929-B2 优先权日:2018-06-04 标 题 :Spirocyclic compounds 发明人:NASVESCHUK CHRISTOPHER G; DEY FABIAN; GOERGLER ANNICK; NORCROSS ROGER; SCHMID PHILIPP 权利人:C4 THERAPEUTICS INC 摘要:The present invention provides compounds and intermediates. The present invention also provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.
专利号:EP-0539274-B1 优先权日:1991-10-24 标题 :Method for the synthesis of aldehydes and of their derivatives
专利号:JP-3615811-B2 优先权日:1991-10-24 标 题 :Catalysts for the synthesis of aldehydes and their derivatives
[参考文献]: R L Siegle, Et Al. In Vitro Complement Consumption By Contrast Materials And Analogues: Reactors Vs. Nonreactors. Invest Radiol. 1983 Jul-Aug;18(4):387-9.
合成参考文献
摘要:A. Bryson and R. W. Matthews, Aust. J. Chem. 16, 401 (1963).