CAS: 5350-94-7; Ethyl 7-Chloro-4-Hydroxy-8-Methylquinoline-3-Carboxylate

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70271-77-1 73987-37-8 405923-50-4

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CAS号58666-10-7 diethyl 2-(((3-... | CAS号87-60-5 3-氯-2-甲基苯胺 | CAS号87-13-8 乙氧甲叉 | CAS号405923-50-4 7-氯-4-羟基-8-甲基喹啉-3-羧酸

📜3-氯-2-甲基苯胺 以 Various Solvent(S) 作为反应溶剂,化学反应 2.0H,反应生成 7-氯-4-羟基-8-甲基喹啉-3-羧酸乙酯
参考文献:Evaluation Of 3-Carboxy-4(1H)-Quinolones As Inhibitors Of Human Protein Kinase Ck2
标题:Evaluation Of 3-Carboxy-4(1H)-Quinolones As Inhibitors Of Human Protein Kinase Ck2
摘要:Due To The Emerging Role Of Protein Kinase Ck2 As A Molecule That Participates Not Only In The Development Of Some Cancers But Also In Viral Infections And Inflammatory Failures,Small Organic Inhibitors Of Ck2,Besides Application In Scientific Research,May Have Therapeutic Significance. In This Paper,We Present A New Class Of Ck2 Inhibitorss3-Carboxy-4(1H)-Quinolones. This Class Of Inhibitors Has Been Selected Via Receptor-Based Virtual Screening Of The Otava Compound Library. It Was Revealed That The Most Active Compounds,5,6,8-Trichloro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid (7) (Ic50 = 0.3 Mu M) And 4-Oxo-1,4-Dihydrobenzo[h] Quinoline-3-Carboxylic Acid (9) (Ic50 = 1 Am),Are Atp Competitive (K-I Values Are 0.06 And 0.28 Mu M,Respectively). Evaluation Of The Inhibitors On Seven Protein Kinases Shows Considerable Selectivity Toward Ck2. According To Theoretical Calculations And Experimental Data,A Structural Model Describing The Key Features Of 3-Carboxy-4(1H)-Quinolones Responsible For Tight Binding To Ck2 Active Site Has Been Developed.
DOI:10.1021/jm050048T