CAS: 4769-97-5; 4-Nitroindole

上下游产品

1-羟基-4-硝基吲哚 1-Hydroxy-4-Nitroindole 78283-23-5
5-甲氧基-4-硝基吲哚 5-Methoxy-4-Nitroindole 135531-92-9
4-氨基吲哚 4-Amino-1H-Indole 5192-23-4
4-硝基吲哚-3-甲醛 4-Nitroindole-3-Carboxaldehyde 10553-11-4
4-硝基吲哚-2-甲酸 4-Nitro-1H-Indole-2-Carboxylic Acid 16732-60-8
5-Nitrocinnoline 2942-36-1
4-硝基芦竹碱 4-Nitrogramine 7150-46-1
4-硝基吲哚-2-羧酸乙酯 4-Nitro-1H-Indole-2-Carboxylic Acid Ethyl Ester 4993-93-5
1-(4-硝基-1H-吲哚-3-基)-乙酮 3-Acetyl-4-Nitroindole 4769-95-3

2,6-二硝基甲苯置于盐酸,氯化亚砜,Potassium Tert-Butylate,铁粉,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 吡啶,乙醇,二甲基亚砜,Xylene,叔丁醇 作为反应溶剂,化学反应 4.42H,反应生成 4-硝基吲哚
参考文献:与sf-2140和新西霉素相关的2'-脱氧呋喃呋喃糖基吲哚核苷的合成
标题:与sf-2140和新西霉素相关的2'-脱氧呋喃呋喃糖基吲哚核苷的合成
摘要:天然存在的抗生素sf-2140和新西霉素的2'-脱氧核糖呋喃糖类似物是通过适当的吲哚衍生物的钠盐与1-氯-2-脱氧-3,5-二-O-P直接糖基化制备的甲苯甲酰-α-D-Erythropentofuranose(5).因此,处理4-甲氧基-1的钠盐的ħ-吲哚-3-基乙腈(4A与)5提供的被保护的核苷,4-甲氧基-1-(2-脱氧-3,5-二-ø-P甲苯甲酰-β-D-赤藓)-1 ħ吲哚-3-基乙腈(6A中),将其用甲醇钠处理,得到的sf-2140类似物,4-甲氧基-1-(2-脱氧β-D-赤藓)-1 ħ-吲哚-3-基乙腈(图7A).所述neosidomycin类似物(8)的制备是通过治疗1个钠盐ħ吲哚-3-基乙腈(4B)与5以得到阻止中间体1-(2-脱氧-3,5-二-ø-P-甲苯酰基β-D-赤藓)-1 ħ吲哚-3-Ylace-Tonitrile(图6B),接着加入甲醇钠处
DOI:10.1002/jhet.5570250202

专利信息

专利号:US-8642798-B2
优先权日:2004-12-07
标 题:Silacycle compounds and methods of use thereof
发明人：LEIGHTON JAMES LINCOLN; BERGER RICHARD; SHIRAKAWA SEIJI; NOTTE GREGORY T
权利人:LEIGHTON JAMES LINCOLN; BERGER RICHARD; SHIRAKAWA SEIJI; NOTTE GREGORY T; TRUSTEE OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
摘要:The present invention relates to a diastereomeric mixture of Silacycle Compounds and methods for using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis.

专利号:US-8993762-B2
优先权日:2013-03-15
标题 :Total synthesis of thaxtomin A analogues and their intermediates
发明人：HUANG HUAZHANG; YAN DONG; XUE ZHIJIE; ZHANG HONGBO
权利人:MARRONE BIO INNOVATIONS INC; MARRONE BIO INNOVATIONS INC
摘要:Improved synthetic methods for the production of thaxtomin analogs, particularly thaxtomin A, and intermediates therefore such as substituted tryptophans and in particular, 4-nitro-L-tryptophan, and substituted phenyl acrylic acids are disclosed. Bioassays show that the synthetic thaxtomin A is not significantly different from the natural one in herbicidal activity.

专利号:US-10752927-B2
优先权日:2018-03-01
标 题 :Method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures
发明人：BOVILLE CHRISTINA E; ROMNEY DAVID K; ALMHJELL PATRICK J; SIEBEN MICHAELA M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing tryptophans and tryptophan derivatives. The methods include: combining i) an indole substrate or azulene substrate, ii) a serine substrate, and iii) an engineered tryptophan synthase β-subunit (TrpB); and maintaining the resulting mixture under conditions sufficient to form the product compound. The engineered TrpB comprises a PLP binding loop mutation, a helix 1 mutation, a strand 7-8 mutation, or a combination thereof. New TrpB variants are also described.

专利号:US-12195777-B2
优先权日:2018-02-02
标 题 :Polynucleotide synthesis method, kit and system
发明人：HERON ANDREW JOHN
权利人:OXFORD NANEPORE TECH PLC; OXFORD NANOPORE TECH PLC
摘要:The invention relates to new in vitro methods for synthesising a polymer, particularly a polynucleotide molecule, having a pre-defined sequence of units such as nucleotides. For synthesising a polynucleotide molecule the methods involve a process of extending a polynucleotide synthesis molecule with a transfer nucleotide. The methods additionally involve repeating the extension process multiple times to iteratively extend the polynucleotide molecule with multiple transfer nucleotides to generate a new polynucleotide molecule having a pre-defined nucleotide sequence. The invention also relates to in vitro methods of joining multiple synthetic polynucleotides following synthesis to form larger synthetic polynucleotides, as well as devices and systems for performing the extension, synthesis and assembly methods of the invention.

专利号:US-2022396818-A1
优先权日:2019-09-10
标 题:Polynucleotide synthesis method, kit and system
发明人：MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE; WILKINSON MARC GEORGE
权利人:OXFORD NANOPORE TECH PLC
摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.

专利号:US-12037636-B2
优先权日:2018-07-19
标题 :Polynucleotide synthesis method, kit and system
发明人：MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE
权利人:OXFORD NANOPORE TECH PLC
摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.