CAS: 473727-83-2; (R)-2-Hydroxy-N,N-Dimethyl-3-((2-((1-(5-Methylfuran-2-yl)Propyl)Amino)-3,4-Dioxocyclobut-1-En-1-yl)Amino)Benzamide

上下游产品

(R)-1-(5-methylfuran-2-yl)propan-1-amine 3-((2-ethoxy-3,4-diox°Cyclobut-1-en-1-yl)amino)-2-hydroxy-N,N-dimethylbenzamide 3-amino-2-hydroxy-N,N-dimethylbenzamide 5-Methylfurfural

📜3-[(2-乙氧基-3,4-二氧代-1-环丁基-1-氨基]-2-羟基-N,N-二甲基-苄胺,1-(5-甲基呋喃-2-基)丙胺置于1-(5-甲基呋喃-2-基)丙胺体系中,用90的收率获得产物sch 527123; 3-[[3-[(二甲基氨基)羰基]-2-羟基苯基]氨基]-4-[[(R)-1-(5-甲基呋喃-2-基)丙基]氨基]-3-环丁烯-1,2-二酮
参考文献:J. Med. Chem. 2006,49,7603-7606
标题:J. Med. Chem. 2006,49,7603-7606

专利信息

专利号:US-8519168-B2
优先权日:2007-07-03
标 题 :Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
发明人：FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; MCALLISTER TIMOTHY L; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI
权利人:FU XIAOYONG; GUENTER FRANK BRUNO; KIM-MEADE AGNES S; MATTHEWS KENNETH STANLEY; MAUST MATHEW THOMAS; WERNE GERALD; WINTERS JASON L; YIN JIANGUO; ZHANG SHUYI; MOLOZNIK DAVID J; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.

专利号:US-8207221-B2
优先权日:2004-01-30
标 题:Crystalline polymorphs of a CXC-chemokine receptor ligand
发明人：HU MENGWEI; YU YOUNONG; DWYER MICHAEL P; TAVERAS ARTHUR G; KIM-MEADE AGNES; YIN JIANGUO; FU XIAOYONG; MCALLISTER TIMOTHY L; ZHANG SHUYI; KLOPFER KEVIN
权利人:HU MENGWEI; YU YOUNONG; DWYER MICHAEL P; TAVERAS ARTHUR G; KIM-MEADE AGNES; YIN JIANGUO; FU XIAOYONG; MCALLISTER TIMOTHY L; ZHANG SHUYI; KLOPFER KEVIN; SCHERING CORP
摘要:The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: n n n n n n n n n n These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.

专利号:US-7910775-B2
优先权日:2003-04-18
标题 :Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
发明人：YIN JIANGUO; FU XIAOYONG; ZHANG SHUYI; MCALLISTER TIMOTHY L; KIM-MEADE AGNES S; WINTERS JASON L; SUDHAKAR ANANTHA; SCHUMACHER DORIS P
权利人:SCHERING CORP
摘要:Disclosed is a process for making the compound of formula I: n nusing the compounds of formulas II, Q, and XI or XII:n n nwherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C 1 -C 10 )alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.

专利号:US-2006205961-A1
优先权日:2003-04-18
标 题:Synthesis of 2-hydroxy-N,N-dimethyl-3-[[2-(1(R)-(5-methyl-2-furany)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide

专利号:US-2009048458-A1
优先权日:2003-04-18
标题:Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide

专利号:EP-1615903-A2
优先权日:2003-04-18
标 题:Synthesis of 2-hydroxy-n,n-dimethyl-3- [[ 2-[ 1(r)-(5-methyl-2-furanyl)propyl] amino] -3,4-dioxo-1-cyclobuten- 1-yl] amino benzamide