CAS: 431-38-9; 3-Amino-1,1,1-Trifluoropropan-2-Ol

相似化合物

3832-24-4 160706-71-8 1217730-60-3

上下游产品

CAS号359-41-1 1,1,1-三氟-2,3-环氧丙烷 | CAS号453-35-0 1,1,1-三氟-3-硝基-2-丙醇 | CAS号453-34-9 4,4,4-三氟-3-羟基丁胺 | CAS号160706-71-8 (2S)-3-氨基-1,1,1...

📜(5Z,8Z,11Z,14Z)-N-(3,3,3-Trifluoro-2-Hydroxypropyl)Icosa-5,8,11,14-Tetraenamide置于maltose-Binding Protein-Recombinant Fatty Acid Amide Hydrolase体系中,用 Aq. Phosphate Buffer,重水 作为反应溶剂,化学反应生成 3-氨基-1,1,1-三氟丙烷-2-醇
参考文献:基于片段的n-Fabs NMR筛选应用于膜酶faah的开发
标题:基于片段的n-Fabs NMR筛选应用于膜酶faah的开发
摘要:片段的氟:我们证明了基于19 F NMR片段的生化筛选(n-Fabs)在膜蛋白脂肪酸酰胺水解酶(faah)上的首次应用.通过这种方法鉴定出的片段命中具有对faah的微摩尔抑制值,显示了该方法在其他膜蛋白应用中的潜力.s:底物,P:产品.
DOI:10.1002/cbic.201300347

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.