CAS: 36039-35-7; 2-[4-(2-Methylpropyl)Phenyl]Ethanol

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CAS号63942-77-8 9-(2-methylprop... | CAS号4654-39-1 4-溴苯乙醇 | CAS号4360-68-3 2-(4-Bromopheny... | CAS号99-90-1 4-溴苯乙酮 | CAS号15687-27-1 布洛芬 | CAS号65322-85-2 3-(4-异丁基苯基)丙酸 | CAS号1553-60-2 异丁芬酸

📜4-溴苯乙酮置于四(三苯基膦)钯,对甲苯磺酸,9-硼双环[3.3.1]壬烷,Sodium Hydroxide体系中,用 四氢呋喃,水,甲苯,苯 作为反应溶剂,化学反应 36.0H,反应生成 4-(2-甲基丙基)苯乙醇
参考文献:缩醛和缩酮的还原裂解与9-硼双环[3.3.1]壬烷†
标题:缩醛和缩酮的还原裂解与9-硼双环[3.3.1]壬烷†
摘要:苯甲醛缩醛和苯乙酮缩酮与空气稳定的结晶9-Borabicyclo [3.3.1]壬烷二聚体的还原裂解分别提供了二醇和1,2-氧-转位的β-苯乙醇的单苄基醚衍生物.通过简单的方法有效地回收硼部分,该方法涉及方便的空气稳定试剂和硼副产物.该方法对于1,3-二醇是特别选择性的,仅给出更多取代的单苄基醚衍生物.用苯乙酮缩酮既发生还原又消除,使9-Bbn-H氢硼化所得的苯乙烯,从而干净地生产1,2-氧转位的β-苯乙醇.该新方法的潜在应用已通过迷幻剂,甲斯卡林和止痛药布非那克的合成得到了说明.
DOI:10.1021/op0601262

专利信息

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:US-5055611-A
优先权日:1990-12-04
标题 :Process for recycling and regenerating carbonylation catalyst used in synthesis of ibuprofen
发明人：LIN RONNY W; HERNDON JR R CARL; ATKINSON JR E E
权利人:ETHYL CORP
摘要:A process for preparing ibuprofen is described. The improved process involves the treatment of spent palladium carbonylation catalyst with oxygen at about 300° C. to about 850° C. The treated material then used with a phosphine ligand to carbonylate 1-halo-1-(4-isobutyl-phenyl)ethane, 1-hydroxyl-1-(4-isobutylphenyl)ethane, or isobutylstyrene to produce ibuprofen.

专利号:WO-9313046-A1
优先权日:1991-12-27
标题:Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines

专利号:EP-0641304-A4
优先权日:1991-12-27
标题:STEREOSPECIFIC SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY USING CHIRAL OXAZOLINES.

专利号:EP-0641304-B1
优先权日:1991-12-27
标题:Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines

专利号:EP-0641304-A1
优先权日:1991-12-27
标题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines