诺龙,正癸酸,N,N'-二环己基碳二亚胺,溶剂黄146置于4-二甲氨基吡啶,对甲苯磺酸体系中,用 二氯甲烷,水合甲醇 用作溶剂,化学反应 5.0H,以the Same Work-Up Procedure As In Example 6 Gives 7.6 G Of Pure 19-Nortestosterone Decanoate (88% Yield) As White Crystals From Methanol/water的收率获得癸酸诺龙 参考文献:Steroid Esters Preparation 标题:Steroid Esters Preparation 摘要:本发明涉及一种改进的类固醇酯合成方法,其中使用肼基脲和4-(三级氨基)-吡啶的催化量与酸催化剂相结合作为缩合剂,可以得到高产率的纯净,不变色化合物.
专利号:US-6333317-B1 优先权日:1997-03-28 标 题:Regulation of amyloid precursor protein (APP) expression by administration of an estrogenic compound 发明人:LEE ROBERT K K; WURTMAN RICHARD J 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:It has been discovered that lipophilic hormones that interact with cytosolic or nuclear receptors regulate APP expression and synthesis, through modification of APP mRNA stability and/or regulation of APP gene transcription and translation activities. These studies demonstrate that the treatment of brain cells with estrone or 17β-estradiol results in a reduction in the level of APP holoprotein expression, without a concomitant change in the total level of cell protein. The reduction in the level of APP holoprotein caused by estrone or 17β-estradiol is also expected to reduce the production of neurotoxic APP fragments. In as much as estrogen deficiency in postmenopausal women is associated with a higher incidence of Alzheimer's disease, this discovery opens the possibility that estrogen therapy may prevent some of the neurodegenerative and cognitive changes associated with Alzheimer's disease, aging and other disease conditions associated with such neurodegenerative and cognitive decline.
专利号:RU-2056430-C1 优先权日:1991-06-26 标 题 :СпоÑ?об получениÑ? Ñ?Ñ?тра-1,3,5(54)method of synthesis of estra-1,3,5(10)-triene-3-ol-17-one
专利号:US-2007148246-A1 优先权日:2005-08-11 标题:Nucleic Acid-Based Matrixes 发明人:LUO DAN; LI YOUGEN 权利人:LUO DAN; LI YOUGEN 摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.
专利号:US-2025281509-A1 优先权日:2021-04-26 标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer 发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER 权利人:UNIV JOHNS HOPKINS 摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.
专利号:US-8486621-B2 优先权日:2005-08-11 标题 :Nucleic acid-based matrixes 发明人:LUO DAN; UM SOONG HO 权利人:LUO DAN; UM SOONG HO; CORNELL RES FOUNDATION INC 摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.
专利号:RU-2105000-C1 优先权日:1996-10-30 标题 :[poly-(2,5-dihydroxyphenylene)]-4-thiosulfoacid sodium salt as regulating agent of cell metabolism and a method of its synthesis
参考文献:10.1016/j.steroids.2011.06.011 摘要:Kailanto S, Kankaanpää A, Seppälä T. Subchronic steroid administration induces long lasting changes in neurochemical and behavioral response to cocaine in rats. Steroids. 2011 Nov;76(12):1310–6. doi: 10.1016/j.steroids.2011.06.011. 参考文献:10.1155/2011/601434 摘要:Donohoe CL, Ryan AM, Reynolds JV. Cancer Cachexia: Mechanisms and Clinical Implications. Gastroenterology Research and Practice. 2011;2011():1–13. doi: 10.1155/2011/601434.