CAS: 349-46-2; D-Cystine

相似化合物

56-89-3 923-32-0 10389-65-8

上下游产品

CAS号2591-17-5 D-(-)-荧光素

Dl-胱氨酸置于盐酸,番木鳖碱体系中,化学反应生成 D-胱氨酸
参考文献:Duvigneaud; Dorfmann; Loring,Journal Of Biological Chemistry,1932,Vol. 98,P. 581
标题:Duvigneaud; Dorfmann; Loring,Journal Of Biological Chemistry,1932,Vol. 98,P. 581

专利信息

专利号:WO-2009107771-A1
优先权日:2008-02-27
标题:Method for synthesis of peptide using gold-iron oxide composite nanoparticle
发明人：KOGA YUICHI; YAMAMOTO TAKAO A; SEINO SATOSHI; TAKANO KAZUFUMI; TOHNAI NORIMITSU; KUWABARA MASAYUKI
权利人:UNIV OSAKA; KOGA YUICHI; YAMAMOTO TAKAO A; SEINO SATOSHI; TAKANO KAZUFUMI; TOHNAI NORIMITSU; KUWABARA MASAYUKI
摘要:Disclosed is a method for the synthesis of a peptide by using a gold-iron oxide composite nanoparticle. Particularly disclosed are: a composite nanoparticle-peptide complex which can be screened with a magnetic force; and an advantageous method for the synthesis of a peptide library composed of the composite nanoparticle-peptide complex. The method for the synthesis of a peptide comprises the steps of: adsorbing a linker molecule on the surface of gold in a gold-iron oxide composite nanoparticle; and synthesizing the peptide through the linker molecule by employing solid-phase peptide synthesis. The method for the synthesis of a peptide library comprises the steps of: adsorbing a linker molecule on the surface of gold in a gold-iron oxide composite nanoparticle; and synthesizing the peptide through the linker molecule by employing split synthesis.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-2021130409-A1
优先权日:2017-09-01
标 题 :Method for the Solid-Phase Synthesis of Cyclic Pentapeptides
发明人：ZHENGGUO JIANG; LUCIANO FORNI; ROBERTSON ALAN
权利人:Alsonex Pty Ltd
摘要:A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan-arginine pentapeptide of Formula A; n n n n n n n n n n n n wherein R 1 and R 2 are, independently, —H, or —C(O)R 3 where R 3 is —CH 2 Ph, —CH 2 CH 2 Ph, —CHâ•?CHPh, —C(NHAC)CH 2 Ph;n nthe method comprising the steps of;n nforming a linear proline-D-cyclohexylalanine-tryptophan-arginine-ornithine pentapeptide of Formula B, attached to a polymeric resin;n n n n n n n n n n n n n n n n n wherein R 1 is as for Formula A, RES indicates the polymeric resin, and P 1 and P 2 are protecting groups;n ncyclising the linear pentapeptide of Formula B to form a cyclic pentapeptide of Formula C, attached to the polymeric resin;n n n n n n n n n n n n n n n cleaving the cyclic peptide of Formula C from the resin providing a cleaved cyclic pentapeptide having a free amine group of an ornithine residue;n noptionally substituting the free amine group of the ornithine residue of the cleaved cyclic peptide;n nremoving the protecting groups P 1 and P 2 , to providethe cyclic peptide of Formula A.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-5198465-A
优先权日:1991-06-19
标题:Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen
发明人：DIOGUARDI FRANCESCO S
权利人:DIOGUARDI FRANCESCO S
摘要:A composition based on aminoacids and free from hydroxy-proline or hydroxy-lysine useful for preventing and treating precursors deficiencies in the synthesis of collagen comprising proline, glycine, lysine, vitamin C, and one or more compounds selected in the group consisting of alpha -ketoglutaric acid, methionine, cysteine, cystine, valine as well as pharmaceutically acceptable diluents and excipients is described.