CAS: 3061-88-9; (S)-2-((S)-2-Aminopropanamido)-3-(4-Hydroxyphenyl)Propanoic Acid

该化合物是一种由氨酸L-aline和L-tyrosine结合的二酸二酸酯,由丙酸结合物连接,其特点是分子结构,包括氨基组,碳球体组和一个有助于其独特特性的侧链,该化合物表面一般白色,表面白色,在水中溶解,适合各种生物应用;L-Alanyl-L-tyrosine,因其在蛋白质合成中的潜在作用和作为...

结构式图片

相似化合物

3061-91-4 730-08-5 658-79-7

上下游产品

L-tyrosine ethyl ester α-bromopropionyl bromide N-(N-benzyloxycarbonyl-L-alanyl)-L-tyrosine benzyl esterN-(N-benzyloxycarbonyl-L-alanyl)-L-tyrosine benzyl ester N-benzyloxycarbonyl-L-alanyl-L-tyrosineN-(dibutyloxyphosphoryl)-L-alanyl-L-tyrosine B°C-Cys(MBzl)-Ala-Gly-Ala-Tyr-OH Ala-Tyr-OMe 16H20N2O5C16H20N2O5

合成工艺路线路线简述

    Z-Ala-Tyr-Oh置于氢气体系中,化学反应生成 丙氨酰-L-酪氨酸
    参考文献:Kawasaki,Koichi; Maeda,Mitsuko; Tamura,Hiromi,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 5,P. 1717-1723
    标题:Kawasaki,Koichi; Maeda,Mitsuko; Tamura,Hiromi,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 5,P. 1717-1723

    海关参考信息

    专利信息


    专利号:US-5801047-A
    优先权日:1992-11-25
    标题:Method for making stable extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
    发明人:DELLA-CIOPPA GUY RICHARD; GARGER JR STEPHEN JOHN; HOLTZ RICHARD BARRY; MCCULLOCH MICHAEL JAY; SVERLOW GENADIE GLEB
    权利人:BIOSOURCE TECH INC
    摘要:A process for the in vitro production of chemically modified polyphenolic polymer (PPP). First, stable, highly active extracellular tyrosinase is produced from genetically transformed microorganism such as Streptomyces antibioticus. The tyrosinase is then incubated with a reaction substrate such as 1-tyrosine, hydrolyzed protein, or an oligopeptide in combination with 1-tyrosine. The ratio of the oligopeptide/tyrosine combination as well as variation in the concentration of tyrosinase can be used to modify the color, the molecular size, and the spectral absorbance properties of the PPP produced. Alternatively, or additionally, oxidants such as hydrogen peroxide or hypochlorite can be used to modify the color of the PPP, regardless of the method used to produce the PPP, and the PPP can subsequently be fractionated using molecular weight cut-off ultrafiltration. Organic solvents can also be used in the method of making PPP to produce PPPs having variable but reproducible physical properties.

    专利号:US-5859190-A
    优先权日:1997-02-04
    标题 :Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
    发明人:MEYER JEAN-PHILIPPE; OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.

    专利号:WO-2024222082-A1
    优先权日:2023-04-28
    标 题 :Amino acid-derived ceramide, synthesis method therefor and use thereof
    发明人:YANG CHAOWEN; YE LIU; LIU LIANGXIAN
    权利人:SHENZHEN DIKEMAN BIOTECHNOLOGY CO LTD
    摘要:An amino acid-derived ceramide, having a structure of general formula I or an isomer of general formula I: (I), wherein M is R 3 or (II), and the R 1 is a residue after condensation of a polypeptide; the R 3 is selected from alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, L-glutamic acid-1-tert-butyl ester, or a residue after condensation of a polypeptide; the polypeptide is formed by condensation of 2-10 amino acids; R 2 is selected from one of the following structures: -C 15 H 29 , -C 15 H 31 , -C 15 H 27 , -CHOHC 14 H 27 , and -CHOHC 14 H 29 . The compound exhibits excellent effects in moisturizing, anti-oxidation, anti-glycation, skin barrier repair, tissue healing, etc.

    专利号:WO-2009056901-A1
    优先权日:2007-10-31
    标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides

    专利号:US-5792649-A
    优先权日:1992-11-25
    标题 :Method for making stable, extracellular tyrosinase and synthesis of polyphenolic polymers therefrom

    专利号:US-9751911-B2
    优先权日:2012-11-27
    标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof
    发明人:REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN
    权利人:COUNCIL SCIENT IND RES
    摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.
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    主要参考文献


    1: Sawai H, Taira H, Ishibashi K, Itoh M. Synthesis and biological activities of beta-alanyltyrosine derivative of 2',5'-oligoadenylate, and its use in radiobinding assay for 2',5-oligoadenylate. J Biochem. 1987 Feb;101(2):339-46. doi: 10.3390/molecules19044246. doi: 10.1016/j.foodchem.2015.04.092. Epub 2015 Apr 23. doi: 10.1021/acs.bioconjchem.5b00049. Epub 2015 Mar 12. doi: 10.1021/mp500671j. Epub 2015 Jul 15. doi: 10.1038/srep14412.
    8: Zhang Z, Zhao Y, Wang X, Lin R, Zhang Y, Ma H, Guo Y, Xu L, Zhao B. The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Food Funct. 2016 Apr;7(4):1975-84. doi: 10.1039/c5fo01302j. doi: 10.1111/cbdd.12257. doi: 10.1002/bio.2773. Epub 2014 Oct 14. doi: 10.7150/thno.7759. eCollection 2014.
    12: Pérez M, Wappner P, Quesada-Allué LA. Catecholamine-beta-alanyl ligase in the medfly Ceratitis capitata. Insect Biochem Mol Biol. 2002 Jun;32(6):617-25. doi: 10.1007/s11307-012-0557-z. doi: 10.1021/bc200319q. Epub 2011 Sep 27. doi: 10.1002/chem.201101894. Epub 2011 Aug 4.

    合成参考文献


    摘要:T. Wieland and H. Bende. Chem. Ber. 98, 504 (1965).
    参考文献:10.1021/jm0511029
    摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029.
    参考文献:10.1186/1476-511x-10-85
    摘要:Inoue N, Nagao K, Sakata K, Yamano N, Gunawardena PER, Han S, Matsui T, Nakamori T, Furuta H, Takamatsu K, Yanagita T. Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo. Lipids in Health and Disease. 2011 May 22;10(1):85. doi: 10.1186/1476-511x-10-85.
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