专利号:US-5801047-A 优先权日:1992-11-25 标题:Method for making stable extracellular tyrosinase and synthesis of polyphenolic polymers therefrom 发明人:DELLA-CIOPPA GUY RICHARD; GARGER JR STEPHEN JOHN; HOLTZ RICHARD BARRY; MCCULLOCH MICHAEL JAY; SVERLOW GENADIE GLEB 权利人:BIOSOURCE TECH INC 摘要:A process for the in vitro production of chemically modified polyphenolic polymer (PPP). First, stable, highly active extracellular tyrosinase is produced from genetically transformed microorganism such as Streptomyces antibioticus. The tyrosinase is then incubated with a reaction substrate such as 1-tyrosine, hydrolyzed protein, or an oligopeptide in combination with 1-tyrosine. The ratio of the oligopeptide/tyrosine combination as well as variation in the concentration of tyrosinase can be used to modify the color, the molecular size, and the spectral absorbance properties of the PPP produced. Alternatively, or additionally, oxidants such as hydrogen peroxide or hypochlorite can be used to modify the color of the PPP, regardless of the method used to produce the PPP, and the PPP can subsequently be fractionated using molecular weight cut-off ultrafiltration. Organic solvents can also be used in the method of making PPP to produce PPPs having variable but reproducible physical properties.
专利号:US-5859190-A 优先权日:1997-02-04 标题 :Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein 发明人:MEYER JEAN-PHILIPPE; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.
专利号:WO-2024222082-A1 优先权日:2023-04-28 标 题 :Amino acid-derived ceramide, synthesis method therefor and use thereof 发明人:YANG CHAOWEN; YE LIU; LIU LIANGXIAN 权利人:SHENZHEN DIKEMAN BIOTECHNOLOGY CO LTD 摘要:An amino acid-derived ceramide, having a structure of general formula I or an isomer of general formula I: (I), wherein M is R 3 or (II), and the R 1 is a residue after condensation of a polypeptide; the R 3 is selected from alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, L-glutamic acid-1-tert-butyl ester, or a residue after condensation of a polypeptide; the polypeptide is formed by condensation of 2-10 amino acids; R 2 is selected from one of the following structures: -C 15 H 29 , -C 15 H 31 , -C 15 H 27 , -CHOHC 14 H 27 , and -CHOHC 14 H 29 . The compound exhibits excellent effects in moisturizing, anti-oxidation, anti-glycation, skin barrier repair, tissue healing, etc.
专利号:WO-2009056901-A1 优先权日:2007-10-31 标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides
专利号:US-5792649-A 优先权日:1992-11-25 标题 :Method for making stable, extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
专利号:US-9751911-B2 优先权日:2012-11-27 标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof 发明人:REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN 权利人:COUNCIL SCIENT IND RES 摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.
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