CAS: 268734-34-5; Methyl 4-Cyano-3-Fluorobenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号201230-82-2 carbon monoxide | CAS号105942-08-3 4-溴-2-氟苯腈 | CAS号176508-81-9 3-氟-4-氰基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号222978-02-1 2-氟-4-(羟甲基)苄甲腈 | CAS号176508-81-9 3-氟-4-氰基苯甲酸

2-氟-4-溴苯腈置于三乙胺体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应生成4-氰基-3-氟苯甲酸甲酯
参考文献:Farnesyltransferase Inhibitors
标题:Farnesyltransferase Inhibitors
摘要:具有以下化学式的取代咪唑和噻唑对抑制法尼基转移酶具有用处.还公开了抑制法尼基转移酶的组合物和在患者中抑制法尼基转移酶的方法.

专利信息

专利号:WO-0027627-A1
优先权日:1998-11-12
标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
发明人：WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.