CAS: 26198-21-0; 6-(Trifluoromethyl)-1H-Benzo[d][1,2,3]Triazol-1-Ol

该化合物是一种化学化合物,具有三联星环,由五人组成,含有三个氮原子的异环结构,该化合物的特点是存在一个氢氧基(-OH)和三氟甲基组(-CF3),该组与苯环相连,对其化学特性和再活性有重大影响.三氟甲基组已知具有传播亲脂性,增强化合物稳定性,而氢基环可参与氢联结,影响溶性,并与其他分子互动.该组可展示生物活动,使其对制药和农用化学研究感兴趣.该组的独特结构允许在各个领域潜在应用,包括材料科学和有机合成.与许多三联苯衍生物一样,它也可能具有杀菌或杀菌特性,尽管具体的生物活动需要进一步调查.

结构式图片

相似化合物

2592-95-2 1548-67-0 123333-53-9

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号121-17-5 4-氯-3-硝基三氟甲苯 | CAS号110-89-4 六氢吡啶 | CAS号110-91-8 吗啉 | CAS号1660-04-4 1-金刚烷甲酮 | CAS号7575-82-8 1-硝基金刚烷

合成工艺路线路线简述

    📜4-氯-3-硝基三氟甲苯置于一水合肼体系中,用 乙醇 用作溶剂,以87 %的收率获得1-羟基-6-(三氟甲基)苯并三唑
    参考文献:光氧化还原催化芳烃的 C−h 氟甲氧基化
    标题:光氧化还原催化芳烃的 C−h 氟甲氧基化
    摘要:通过 N-羟基苯并三唑与氟乙酸的电羧化 C(Sp 3 )-O 偶联和随后的烷基化,合成了一类新的 [n−och 2 F] 氧化还原活性试剂.通过在存在光敏剂的情况下用蓝色 Led 照射,这些稳定的试剂允许通过 C-H 键的功能化合成单氟甲基芳基醚.
    Doi:10.1002/anie.202215920

    海关参考信息

    专利信息


    专利号:US-7807821-B1
    优先权日:2004-03-01
    标题 :Method for the synthesis of nucleic acid without protecting base moiety
    发明人：SEKINE MITSUO; SEIO KOHJI; OHKUBO AKIHIRO
    权利人:JAPAN SCIENCE & TECH AGENCY
    摘要:A phosphoramidite method for the synthesis of a nucleic acid oligomer without protecting the base moiety characterized in that a 3′ or 5′ hydroxyl group of a nucleotide is reacted with a nucleoside phosphoramidite, a cyclonucleoside phosphoramidite, a 2′-substituted nucleoside phosphoramidite, a 4′-substituted nucleoside phosphoramidite, or a 2′,4′-di-substituted nucleoside phosphoramidite to produce a phosphodiester linkage. The phosphoramidite is contacted with an activator containing both a) hydroxybenzotriazole-1-ol (HOBt), a mono-substituted HOBt, a di-substituted HOBt, or a di-substituted phenol and b) imidazole, tetrazole, benzimidazoletriflate (BIT), 4-ethylthiotetrazole, imidazolium triflate(trifluoromethane sulfonate) or 4,5-dicyanoimidazole.

    专利号:US-2014309424-A1
    优先权日:2011-06-30
    标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine
    发明人：BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN
    权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA
    摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.

    专利号:US-6310198-B1
    优先权日:1993-01-08
    标题:Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
    发明人：TANG JIN-YAN; BONGLE NANDKUMAR; GONZALEZ JOSE; SCHWARTZ WARREN E
    权利人:AVECIA BIOTECHNOLOGY INC
    摘要:The present invention comprises an improved method of synthesizing oligonucleotides. The method comprises employing dinucleotides (or 'dimer blocks') as the basic synthetic unit building block. The method results in extremely high purity oligonucleotides in which the N-1 content is very low, generally less than 1-2% of the full length, N, oligonucleotide. We have found that synthesis using dinucleotide phosphorothioates results in oligonucleotides having very little phosphodiester content. Furthermore, we have found that the amount of dimer required in each coupling step can be less than about 6 and is preferably about 2 equivalents. Synthesis of oligonucleotides according to the dimer block approach described herein can also be conducted without the capping step that has heretofore been deemed necessary after each coupling.

    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

    专利号:US-3725380-A
    优先权日:1969-04-05
    标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
    发明人：KONIG W; GEIGER R
    权利人:HOECHST AG
    摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

    专利号:KR-20140063577-A
    优先权日:2011-06-30
    标 题 :Direct synthesis of 18F-fluoromethoxy compounds for PET imaging and the provision of novel precursors for direct radiative synthesis of protected derivatives of O - ([18F] fluoromethyl) tyrosine

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 141.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知