N-Cbz-D-苯丙氨醛置于chromium(Vi) Oxide,硫酸体系中,用 水,丙酮 用作溶剂,化学反应生成N-苄氧羰基-D-苯丙氨酸 参考文献:Asymmetric Carbon To Nitrogen Bond Formation Using Optically-Active Allylic Selenides: A New General Method For The Synthesis Of N-Protected Optically-Active .Alpha.-Amino Acids 标题:Asymmetric Carbon To Nitrogen Bond Formation Using Optically-Active Allylic Selenides: A New General Method For The Synthesis Of N-Protected Optically-Active .Alpha.-Amino Acids 摘要: Doi:10.1021/jo00203A037
专利号:US-5116741-A 优先权日:1988-04-12 标题 :Biosynthetic uses of thermostable proteases 发明人:BRYAN PHILIP N; PANTOLIANO MICHAEL W; ROLLENCE MICHELE L; WONG CHI H 权利人:GENEX CORP 摘要:The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.
专利号:US-5499193-A 优先权日:1991-04-17 标题:Automated synthesis apparatus and method of controlling the apparatus 发明人:SUGAWARA TOHRU; KATO SHINJI 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:An automatic synthesizing apparatus for continuously effecting automatically by a controlling apparatus all the operations including the supplying of samples into reaction vessel and so on, reaction processing of the contents within the reaction vessels, PH adjustment, extraction/dehydration processing, purification of the contents, and further analysis of the reaction condition so as to produce the target compounds. Many basic unit operation procedures are made and stored so that programs for effecting the operation controlling of the automatic synthesizing apparatus may be extremely easily made. The innumerable syntheses programs in the chemical experiments may be effected simply by the inputting of the operation names of the unit operation procedures in the operational orders when the synthesis order programs may be made for each target compound.
专利号:EP-0510487-B1 优先权日:1991-04-17 标题:Automated synthesis apparatus and method of controlling the apparatus 发明人:SUGAWARA TOHRU; KATO SHINJI 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:An automatic synthesizing apparatus (I,II) for continuously effecting automatically by a controlling apparatus (II) all the operations including the supplying of samples into reaction vessel and so on, reaction processing of the contents within the reaction vessels (12), PH adjustment (13), extraction/dehydration processing (14), purification (16) of the contents, further analysis (15) of the reaction condition so as to produce the target compounds. Many basic unit operation procedures are made, stored so that programs for effecting the operation controlling of the automatic synthesizing apparatus may be extremely easily made. The innumerable syntheses programs in the chemical experiments may be effected simply by the inputting of the operation names of the unit operation procedures in the operational orders when the synthesis order programs may be made for each target compound.
专利号:CN-102686601-A 优先权日:2009-11-16 标 题 :Synthesis of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2
专利号:WO-9209620-A1 优先权日:1990-11-30 标题 :Solution phase process for synthesis of peptide 发明人:STEVENSON DAVID 权利人:SMITHKLINE BEECHAM CORP 摘要:A solution phase process for preparing L-His-D-Trp-L-Ala-L-Trp-D-Phe-L-Lys-NH2, a peptide which has pituitary growth hormone releasing activity, is described.
专利号:EP-0564587-A4 优先权日:1990-11-30 标 题:Solution phase process for synthesis of peptide
参考标题:Solid-Phase Synthesis Of C-Terminal Peptide Aldehydes From Amino Acetals Anchored To A Backbone Amide Linker (Bal) Handle 作者:Fanny Guillaumie,Joseph C Kappel,Nicholas M Kelly,George Barany,Knud J Jensen |发布日期:2000.8 摘要:Peptide Aldehydes Were Synthesized, Starting From Amino Acetals, By A Solid-Phase Backbone Amide Linker (Bal) Strategy.
合成参考文献
参考文献:10.1021/jm00027a027 摘要:Ye QZ, Johnson LL, Nordan I, Hupe D, Hupe L. A recombinant human stromelysin catalytic domain identifying tryptophan derivatives as human stromelysin inhibitors. J Med Chem. 1994 Jan 07;37(1):206–9. doi: 10.1021/jm00027a027. 参考文献:10.1007/s10529-005-0018-8 摘要:Salam SM, Kagawa K, Kawashiro K. Alpha-chymotrypsin-catalyzed peptide synthesis using N-protected D-amino acid carbamoylmethyl esters as acyl donors. Biotechnol Lett. 2005 Aug;27(16):1199–203. doi: 10.1007/s10529-005-0018-8.