CAS: 20780-53-4; (R)-2-Phenyloxirane

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Alpha-氯乙酰苯置于sodium Formate体系中,用 水 用作溶剂,以95%的收率获得(R)-环氧苯乙烷
参考文献:铑/二胺双官能化介孔结构二氧化硅纳米粒子的多步有机转化
标题:铑/二胺双官能化介孔结构二氧化硅纳米粒子的多步有机转化
摘要:在非均相不对称催化中,在一个介孔二氧化硅中将多种催化官能团作为催化剂用于环境友好介质中的多步对映选择性有机转化是一个重大挑战.在本文中,我们采取了bf的优点4-阴离子氢键策略来锚手性阳离子铑/二胺碱官能化的介孔结构的二氧化硅纳米粒子内复杂方便地构造一个双功能的非均相催化剂.固态13 C NMR光谱揭示了定义明确的手性rh /二胺活性物质,我们使用了xrd,N 2吸附-解吸和电子显微镜揭示有序的介观结构.二氧化硅纳米粒子中双官能团的结合实现了两种高效的对映选择性有机转化,具有高收率和对映选择性,其中α-卤代酮的不对称转移加氢,然后环氧化提供了各种手性芳基氧杂环戊烷,以及随后将α-卤代酮与苯胺胺化通过不对称转移氢化产生各种β-氨基醇.此外,该催化剂可被回收和再循环七次而不会损失催化活性,这对于可持续的良性过程中的多步有机转化而言是一个吸引人的特征.
Doi:10.1002/cctc.201700436

专利信息

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

专利号:US-2009182016-A1
优先权日:2006-05-23
标题 :Optical enantiomers of phenyramidol and process for chiral synthesis
发明人：DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
权利人:DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
摘要:The present invention discloses optically pure (R) and (S) Phenyramidol enantiomers and their pharmaceutically acceptable salts, a process for synthesising such enantiomers by means of a styrene oxide based asymmetric synthesis, and also a clinical evaluation of (R) and (S) enantiomers of Phenyramidol, their salts and compositions thereof for enhanced/newer therapeutic benefits.

专利号:US-8389551-B2
优先权日:2006-05-23
标题:Optical enantiomers of phenyramidol and process for chiral synthesis
发明人：DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
权利人:DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH; FERMENTA BIOTECH UK LTD
摘要:The present invention discloses optically pure (R) and (S) Phenyramidol enantiomers and their pharmaceutically acceptable salts, a process for synthesizing such enantiomers by means of a styrene oxide based synthesis, and also a clinical evaluation of (R) and (S) enantiomers of Phenyramidol, their salts and compositions thereof for enhanced/newer therapeutic benefits.

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

专利号:WO-2006003790-A1
优先权日:2004-06-30
标 题:Reaction apparatus for hydrophobic compound and method of reaction therewith
发明人：NODA KENICHI; IRISA SHIRO; KOGURE TOMONARI; SAKATA MINORU; TOKIDA AKIHIKO
权利人:BUSSAN NANOTECH RES INST INC; NODA KENICHI; IRISA SHIRO; KOGURE TOMONARI; SAKATA MINORU; TOKIDA AKIHIKO
摘要:A reaction apparatus for hydrophobic compound for carrying out reaction of hydrophobic compounds with the use of a biocatalyst, characterized by having a microchannel chip comprising a first channel for circulation of a hydrophobic liquid material containing a hydrophobic compound, a second channel for circulation of a water base liquid material containing a biocatalyst and a third channel for circulation of the hydrophobic liquid material and water base liquid material which is connected to the first channel and second channel. By virtue of this reaction apparatus, the reaction efficiency of hydrophobic compound can be satisfactorily enhanced in a wide variety of reactions conducted in the presence of a biocatalyst. Accordingly, the provided reaction apparatus for hydrophobic compound and method of reaction therewith are applicable to, being important in organic chemistry, a hydrolysis reaction, redox reaction, transition reaction, substitution reaction, elimination reaction, condensation reaction, addition reaction, isomerization reaction, asymmetric synthesis reaction, etc., and future progress is promising in the field of biocatalytic reaction for hydrophobic compounds.

专利号:WO-2025103462-A1
优先权日:2023-11-17
标题:Substituted 2, 3-dihydrobenzo [d] [1, 3] oxaphosphole ligand, preparation method and use thereof
发明人：CHEN GENQIANG; ZHENG LONGSHENG; LI SHUO; YU JIANCHAO; LU BIN
权利人:SHENZHEN CATALYS TECH CO LTD; SHENZHEN GREENCAT PHARMACEUTICAL TECH CO LTD
摘要:Provided herein are a 2, 3-dihydrobenzo[d][1, 3]oxaphosphole derivative of formula (I) and a preparation method thereof. Compound I was constructed in utilizing tandem nucleophilic addition (or nucleophilic substitution) and intramolecular S NAr reaction. The method has the characteristics of simple operation steps, high yield, and mild reaction conditions. The technical problems of complex and harsh conditions in the synthesis of oxaphosphinine compounds in a conventional prior art were solved.