CAS: 170737-46-9; 6-Bromo-2-Naphthaldehyde

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33626-98-1 5773-80-8 100751-63-1

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CAS号100751-63-1 6-溴-2-萘甲醇 | CAS号33626-98-1 6-溴-2-萘甲酸甲酯 | CAS号5111-65-9 2-溴-6-甲氧基萘

📜6-溴-2-萘甲酸置于硫酸,二异丁基氢化铝体系中,用 四氢呋喃,正庚烷,二氯甲烷 用作溶剂,化学反应 31.0H,反应生成6-溴-2-萘甲醛
参考文献:基于立体特异性[2 + 2]环加成反应驱动的萘丙烯酸动态分子晶体的光致动器
标题:基于立体特异性[2 + 2]环加成反应驱动的萘丙烯酸动态分子晶体的光致动器
摘要:研究了卤素取代萘丙烯酸(1Fnaaa,1Clnaaa,1Brnaaa,1Inaaa和6Brnaaa)的动态分子晶体的光机械效应.在紫外线照射下,1Fnaaa的针状晶体卷曲远离光源,而6Brnaaa的片状晶体向光源弯曲.此外,观测到了细长的1Fnaaa针状晶体以及1Clnaaa和1Brnaaa的片状晶体的光致弯曲,翻转和破裂.显示由365 Nm光触发的弯曲,开裂,卷曲,旋转和扭曲.发现在晶体中发生立体有择的[2 + 2]环加成反应,得到一种β型环丁烷的立体异构体,因为1Fnaaa,1Clnaaa,1Brnaaa和6Brnaaa以头对头的方式堆积,这满足了schmidt的拓扑-光化学标准.可以在光二聚化过程中产生和积累应变,并且应变的释放导致光机械效应.这为基于带有卤素取代的芳族单元的丙烯酸的光机械分子晶体的开发提供了新的线索.
Doi:10.1039/c9Tc06689F

专利信息

专利号:US-2024325572-A1
优先权日:2021-07-15
标 题 :N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives as fluorophors for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders
发明人：SARRAF STELLA T
权利人:AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores of formula I useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the compounds for use in methods for diagnosis and treatment of diseases associated with an amyloid or amyloid like proteins, such as e.g. Alzheimer's disease or traumatic brain injury (TBI), Parkinson's disease, vascular dementia, amyotrophic lateral sclerosis, Down syndrome, traumatic brain injury, chronic traumatic encephalopathy, schizophrenia or depression. Exemplary compounds are e.g. N-heterocyclyl substituted 2-cyano-3-(naphthalen-2-yl)acrylamide derivatives, such as e.g. (E)-2-cyano-N-(2-(2-hydroxy)ethoxy)ethyl)-3-(6-(pyrrolidin-1-yl)naphthalen-2-yl) acrylamide (example 1): Experimental data on in-vitro binding studies with amyloid beta is provided.

专利号:US-11718596-B2
优先权日:2014-03-19
标题 :Amyloid targeting agents and methods of using the same
发明人：YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA
权利人:UNIV CALIFORNIA; AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

专利号:WO-2024155678-A1
优先权日:2023-01-18
标 题 :Amyloid targeting agents
发明人：SARRAF STELLA; SWISS GERALD
权利人:AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.

专利号:CN-106542971-B
优先权日:2015-09-17
标题:A kind of synthesis technology of the bromo- beta naphthal of 6-

专利号:UA-79448-C2
优先权日:2002-02-06
标题 :Derivatives of 3-aryl-2,5-dihydroxy-1,4-benzoquinone, method for synthesis and pharmaceutical composition

专利号:CN-109265393-B
优先权日:2018-11-16
标题:Synthesis method and application of acylhydrazone metal complex with single crystal structure containing naphthalene ring