CAS: 1691249-45-2; (S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-Phenoxyphenyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxamide

上下游产品

Zanubrutinib
2-(4-Phenoxyphenyl)-7-(Piperidin-4-yl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine-3-Carboxamide 1633350-04-5

3-氨基-5-(4-苯氧基苯基)-4-氰基-1H-吡唑置于盐酸,Bis(1,5-Cyclooctadiene)Diiridium(I) Dichloride,甲烷磺酸,C29H30Fenop,氢气,碳酸氢钠,溶剂黄146体系中,用 四氢呋喃,乙醇,二氯甲烷,水,甲苯,乙腈 用作溶剂,85.0~95.0 °C,8.11 Mpa 条件下,反应 76.0H,反应生成泽布替尼
参考文献:吡唑并[1,5-A]嘧啶的高对映选择性 Ir 催化氢化用于合成 Zanubrutinib
标题:吡唑并[1,5-A]嘧啶的高对映选择性 Ir 催化氢化用于合成 Zanubrutinib
摘要:Ir/( R )-T-Bu-Fcphox 复合物实现了吡唑并[1,5-A ]嘧啶高度对映选择性催化还原为 Zanubrutinib.该手性产物在不对称转化中无需任何其他添加剂即可获得高达99% Ee的手性产物,为zanubrutinib的不对称合成提供了新途径.
Doi:10.1021/acs.Joc.3C02446

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-12390420-B1
优先权日:2024-10-22
标题 :Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof
发明人：EGUCHI MASAKATSU
权利人:BRYET US INC
摘要:The present disclosure provides compositions and methods for delivering therapeutic agents to particular tissues or cells in a subject. The composition disclosed herein combines unique properties of porous micro- or nano-particles with host-guest chemistry provided by functionalized silicon particle, offering a versatile approach to addressing the challenges associated with delivering therapeutic agents to target tissues or sites within the body. The present disclosure also provides a method for synthesizing a composition capable of delivering therapeutic agents to particular tissues or cells in a subject.

专利号:US-2009306392-A1
优先权日:2007-10-19
标题 :Gsm intermediates
发明人：HO CHIH YUNG
权利人:HO CHIH YUNG
摘要:The present invention relates the use of compounds having the general Formula I, wherein the definitions or R 1 and R 2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of γ-secretase modulators, which are in turn useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

专利号:CA-2743700-C
优先权日:2008-12-15
标题 :Stereoselective synthesis of piperidine derivatives

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:JP-2012512172-A
优先权日:2008-12-15
标 题:Stereoselective synthesis of piperidine derivatives.