对硝基苯基氯甲酸酯置于吡啶体系中,用 乙酸乙酯 用作溶剂,化学反应生成((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯 参考文献:Process For The Preparation Of Disubstituted Carbonates 标题:Process For The Preparation Of Disubstituted Carbonates 摘要:本发明涉及一种制备碳酸盐化合物的方法,该化合物可用于制备人类免疫缺陷病毒(hiv)蛋白酶抑制剂.该化合物的化学式为i:##str1## 其中r.Sup.9为氢或低碳基,噻唑环可以是未取代的或取代有低碳基的.
专利号:WO-2006090264-A1 优先权日:2005-02-28 标 题 :A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs 发明人:BOSE PROSENJIT; BISWAS SUJOY; RATHORE RAMENDRA SINGH; SACHDEVA YOGINDER PAL; KUMAR YATENDRA 权利人:RANBAXY LAB LTD; BOSE PROSENJIT; BISWAS SUJOY; RATHORE RAMENDRA SINGH; SACHDEVA YOGINDER PAL; KUMAR YATENDRA 摘要:The present invention relates to an improved process for preparing 2-amino-5-protected-amino-3-hydroxy-1,6-diphenylhexane compounds or acid addition salts thereof, which can be useful intermediates for preparing compounds with antiviral activity. The present invention further provides a process for preparing HIV protease inhibitors, lopinavir and ritonavir.
专利号:JP-H1087639-A 优先权日:1992-12-29 标题:Useful intermediates for the synthesis of compounds that inhibit retroviral protease