CAS: 139893-43-9; Ammonium (3R,5R)-7-((1S,2S,6R,8S,8Ar)-8-((2,2-Dimethylbutanoyl)Oxy)-2,6-Dimethyl-1,2,6,7,8,8A-Hexahydronaphthalen-1-yl)-3,5-Dihydroxyheptanoate

辛伐他汀置于氨,水体系中,用 乙酸乙酯 用作溶剂,以75%的收率获得(3R,5R)-7-[(1S,2S,6R,8S,8Ar)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8A-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵
参考文献: Isolation And Recovery Of Simvastatin In Lactone Form Or In The Form Of An Acid Salt From The Harvested Fermentation Broth[fr] Isolement Et Récupération De Simvastatine Sous Forme Lactonique Ou Sous Forme D'Un Sel Acide à Partir D'Un Bouillon De Fermentation Récolté
标题: Isolation And Recovery Of Simvastatin In Lactone Form Or In The Form Of An Acid Salt From The Harvested Fermentation Broth[fr] Isolement Et Récupération De Simvastatine Sous Forme Lactonique Ou Sous Forme D'Un Sel Acide à Partir D'Un Bouillon De Fermentation Récolté

专利信息

专利号:US-5223415-A
优先权日:1990-10-15
标题 :Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
发明人：CONDER MICHAEL J; CIANCIOSI STEVEN J; COVER WILLIAM H; DABORA REBECCA L; PISK ERIC T; STIEBER ROBERT W; TEHLEWITZ BOGDAN; TEWALT GREGORY L
权利人:MERCK & CO INC
摘要:Biosynthetic production of 7-[1',2',6',-7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy -1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, 'triol acid', is accomplished by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula ATCC 38009 or ATCC 74178, or mutants thereof, or a cell-free extract derived therefrom, or a hydrolase derived therefrom. The triol acid and its lactone form are both inhibitors of HMG-CoA reductase and thus useful as anti-hypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors. Also, in the synthesis of simvastatin by direct methylation of lovastatin, selective hydrolysis of residual lovastatin salt by treatment with Clonostachys compactiuscula ATCC 38009 or ATCC 74178 or mutants thereof or a cell-free extract derived therefrom, or a hydrolase derived therefrom yields the 'triol' salt which can be easily separated from simvastatin.

专利号:CN-103725726-A
优先权日:2013-12-24
标 题:Preparation method of enzymatic synthesis of simvastatin

专利号:CN-117903175-A
优先权日:2024-01-11
标 题:A kind of synthesis method and application of lithium pyrrolidine