专利号:US-11708363-B2 优先权日:2020-09-30 标 题:Method for preparing a key intermediate for the synthesis of statins 发明人:CHEN FENER; CHENG DANG; LIU MINJIE; HUANG ZEDU; TAO YUAN; WANG JIAQI 权利人:UNIV FUDAN 摘要:Disclosed herein relates to organic synthesis, and more particularly to a method for preparing a key intermediate for the synthesis of statins. The key intermediate is 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylthio)methyl]-2,2-disubstituted-1,3-dioxan-4-yl] acetate of formula (I): n nwhere R 1 is a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group, a monosubstituted or polysubstituted aryl group, or monosubstituted or polysubstituted aralkyl group; R 2 is hydrogen, or monosubstituted or polysubstituted C 1 -C 3 alkyl group, or halogen; and R 3 and R 4 are each independently a C 1 -C 5 alkyl group, a C 3 -C 7 cycloalkyl group, a C 3 -C 7 cycloalkenyl group, a C 1 -C 3 alkoxy group, a C 6 -C 10 aryl group, or C 7 -C 12 aralkyl group. In the method, a halomethyl compound and a thiol reagent are subjected to nucleophilic substitution in an organic solvent to synthesize a thioether, which then undergoes ketal exchange reaction with a carbonyl compound (V) in the presence of an organic acid to obtain a target product.
专利号:US-9920160-B2 优先权日:2014-09-03 标题 :Method for synthesis of polymer containing multiple epoxy groups 发明人:GAO CHAO; ZHENG YAOCHEN; PENG LI; CAI SHENGYING; WENG ZHULIN 权利人:UNIV ZHEJIANG 摘要:A method for a synthesis of a polymer containing multiple epoxy groups includes steps of: under protection of nitrogen or argon, with a photosensitive free radical initiator under an ultraviolet light irradiation, initiating a mixture of a dithiol compound and alkynyl glycidyl ether or other alkynyl-containing compounds to proceed a thiol-yne polymerization, so as to obtain the polymer. The number of the epoxy groups is able to be adjusted through changing a type of a dithiol monomer, a mixing ratio of the dithiol monomer, and a mixing ratio between the alkynyl glycidyl ether and other alkynyl compounds. The present invention has advantages of: fast reaction, convenient process, easy post-processing, a large number of the epoxy groups, and adjustable and controllable content. The obtained polymer has a wide potential application in fields of coating, adhesive, ink, encapsulating material, resin for composite material, additive, high performance material, function material, and so on.
专利号:US-9929363-B2 优先权日:2013-08-05 标题:Composition and synthesis of aggregation-induced emission materials 发明人:TANG BENZHONG; Xie ni; LAM WING YIP 权利人:UNIV HONG KONG SCI & TECH 摘要:The present subject matter relates to compositions containing and synthesis of fluorescent materials e made from tetraphenylethylene (TPE) derivative compounds exhibiting aggregation induced emission (AIE) properties. Further contemplated herein are applications for TPE derivative compounds such as electroluminescent devices since they have a high efficiency, low turn on voltage, and excellent brightness. Additionally, application of TPE derivatives exhibiting AIE properties in various fields such as OLEDs, fingerprinting and forensic technology, and various other biological and industrial sectors are discussed.
专利号:US-7514465-B2 优先权日:2004-11-16 标题 :Synthesis of N2-(substituted arylmethyl)-3-(substituted phenyl)indazoles as novel anti-angiogenic agents 发明人:KUO SHENG-CHU; HUANG LI-JIAU; LEE FANG-YU; TENG CHE-MING; SHIH MEI-LING; CHEN HUA-SIN 权利人:YUNG SHIN PHARM IND CO LTD 摘要:Novel compounds of 2-(substituted arylmethyl)-3-(substituted phenyl)-2H-indazoles and 1-(substituted arylmethyl)-3-(substituted phenyl)-1H-indazoles are synthesized, and useful as anti-angiogenic agents.
专利号:US-2023212107-A1 优先权日:2021-12-30 标 题:Synthesis of para-alkylated syringyl (meth)acrylate derivatives and photopolymerizable compositions for additive manufacturing in dental applications 发明人:CHOUDHARY UMESH UPENDRA; SU JESSICA KALAY 权利人:ALIGN TECHNOLOGY INC 摘要:The present disclosure provides polymerizable monomers which may be used as reactive diluents in additive manufacturing. The polymerizable monomers may have low vapor pressures and may be compatible with a range of low glass transition temperature oligomers.
专利号:US-8212056-B2 优先权日:2008-06-30 标 题 :Ligands for transition-metals and methods of use 发明人:KWONG FUK YEE; SO CHAU MING 权利人:KWONG FUK YEE; SO CHAU MING; UNIV HONG KONG POLYTECHNIC 摘要:The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.
参考标题:Synthesis Of Biaryls And Aryl KetonesViaMicrowave-Assisted Decarboxylative Cross-Couplings 作者:Lukas J. Gooßen,Bettina Zimmermann,Christophe Linder,Nuria Rodríguez,Paul P. Lange,Jens Hartung |发布日期:2009.11 摘要:A Protocol For The Microwave-Assisted Decarboxylative Cross-Couplings Of Carboxylic Acid Salts With Aryl Halides Has Been Developed That Allows The Synthesis Of Various Biaryls And Aryl Ketones In High Yields. After Careful Adaptation Of The Bimetallic Catalyst System And Reaction Conditions, These Mechanistically Complex Transformations Can Now Be Performed Within Only Five Minutes In Concentrated
合成参考文献
摘要:Pu, L., Science of Synthesis, (2010) 45, 691. 摘要:de Haro, T.; Garayalde, D.; Nevado, C., Science of Synthesis Knowledge Updates, (2012) 2, 220. 摘要:Gagnon, A.; Benoit, E.; Le Roch, A., Science of Synthesis Knowledge Updates, (2018) 4, 81. 摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 464. 摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 405.