CAS: 132373-81-0; (2R,4R)-4-(Dimethylamino)-2-Phenyl-2-(Pyridin-2-yl)Pentanamide

上下游产品

伐米胺 4-(Dimethylamino)-2-Phenyl-2-(2-Pyridyl)Pentanamide 97987-88-7
(+)-(2S,4S)-4-(Dimethylamino)-2-Phenyl-2-(2-Pyridyl)Pentanamide
4-(二甲氨基)-2-苯基-2-(2-吡啶基)戊腈 4-(Dimethylamino)-2-Phenyl-2-(2-Pyridyl)Pentanenitrile 99132-31-7
4-氧代-2-苯基-2-(2-吡啶基)戊腈 4-Oxo-2-Phenyl-2-(2-Pyridyl)Pentanenitrile 101509-01-7

📜苯基吡啶-2-乙腈置于氢氧化钾,Sodium Tetrahydroborate,硫酸,四氯化钛体系中,用 溶剂黄146 用作溶剂,化学反应 6.17H,反应生成(2R,4R)-4-二甲基氨基-2-苯基-2-吡啶-2-基戊酰胺
参考文献:Synthesis And Anticholinergic Activity Of The Four Stereoisomers Of 4-(Dimethylamino)-2-Phenyl-2-(2-Pyridyl)Pentanamide
标题:Synthesis And Anticholinergic Activity Of The Four Stereoisomers Of 4-(Dimethylamino)-2-Phenyl-2-(2-Pyridyl)Pentanamide
摘要:The Four Stereoisomers Of 4-(Dimethylamino)-2-Phenyl-(2-Pyridyl)Pentanamide Were Synthesized,And The Absolute Configurations Were Determined By X-Ray Crystallography. Pharmacological Testing For Anticholinergic Activity Revealed Great Differences In Potency Among 10 (2R,4R,Ic50 = 0.40 Mu M),11 (2S,4S,31 Mu M),12 (2R,4S,170 Mu M),And 13 (2S,4R,0.13 Mu M). A New Drug Application For The Racemate 8 (Fk176,Vamicamide) Has Been Filed In Japan For The Treatment Of Overactive Detrusor Syndrome.
Doi:10.1021/jm00035A019

专利信息

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.