CAS: 1206524-84-6; 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid, 5-(1,1-Dimethylethyl)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-14-Methoxy-3,6-Dioxo-, Methyl Ester, (1Ar,5S,8S,10R,22Ar)-

该化合物是一种复杂的有机化合物,其特点是分子结构复杂,包括多种功能组和立体中心,其特征是四十三氢框架,表明饱和的环状结构,以及表示潜在反应和生物活动的甲氧基和二氧化物组,五氧化二氧基的出现意味着药用化学可能应用,特别是在药品的开发中,其立体化学以特定的R和S配置为标志,对于确定其生物相互作用和特性至关重要.总体而言,该物质体现了合成有机化合物中经常发现的复杂性,这可能导致在各个领域,包括药物开发和材料科学中的各种应用.

英文名称8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid, 5-(1,1-Dimethylethyl)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-14-Methoxy-3,6-Dioxo-, Methyl Ester, (1Ar,5S,8S,10R,22Ar)-
中文名称(1AR,5S,8S,10R,22AR)-5-(叔丁基)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-十四氢-14-甲氧基-3,6-二氧代-8H-7,10-甲桥环丙烯并[18,19][1,10,3,6]二氧杂二氮杂环十九碳九烯并[11,12-B]喹喔啉-8-羧酸甲酯
IUPAC名称8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-, methyl ester, (1aR,5S,8S,10R,22aR)-
其它别名(1Ar,5S,8S,10R,22Ar)-5-(1,1-Dimethylethyl)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-14-Methoxy-3,6-Dioxo-8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid Methyl Ester; Methyl(33R,35S,91R,92R,5S)-5-(Tert-Butyl)-17-Methoxy-4,7-Dioxo-2,8-Dioxa-6-Aza-1(2,3)-Quinoxalina-3(3,1)-Pyrrolidina-9(1,2)-Cyclopropanacyclotetradecaphane-35-Carboxylate; 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid, 5-(1,1-Dimethylethyl)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-14-Methoxy-3,6-Dioxo-, Methyl Ester; 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid, 5-(1,1-Dimethylethyl)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-14-Methoxy-3,6-Dioxo-, Methyl Ester, (1Ar,5S,8S,10R,22Ar)-; Methyl (1Ar,5S,8S,10R,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylate; Methyl (1Ar,5S,8S,10R,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-
CAS编号1206524-84-6
MFCD编号:MFCD28386607
分子式:C30H40N4O7
分子量:568.67
产品CID: 275530
产品分类医药中间体 → 原料药中间体

相似结构搜索
InChIKey: QHQKEFQTKKSZEH-AGLWYXLZSA-N
InChI=1S/C30H40N4O7/c1-30(2,3)25-27(35)34-16-19(15-23(34)28(36)39-5)40-26-21(31-20-12-11-18(38-4)14-22(20)32-26)10-8-6-7-9-17-13-24(17)41-29…
计算化学: 氢键受体数9.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

上下游产品

methyl (1aR,5S,8S,10R,18E,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methan°Cyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 1-(tert-butyl) 2-methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate methyl (4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-L-prolinate hydr°Chloride trans 2-(pent-4-en-1-yl)cyclopropanol (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradeca-hydro-8H-7,10-methan°Cyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid hydrate grazoprevir

合成工艺路线路线简述

N-Boc-反式-4-羟基-L-脯氨酸甲酯置于5%-Palladium/activated Carbon,氢气,1,8-二氮杂双环[5.4.0]十一碳-7-烯,N,N-二异丙基乙胺,苯磺酸体系中,用甲醇,N,N-二甲基乙酰胺,醋酸异丙酯,乙腈用作溶剂,85.0 °C,103.42 Kpa 条件下,反应 14.58H,反应生成Mk-5172中间体
参考文献:实用,不对称合成丙型肝炎病毒蛋白酶抑制剂mk-5172的开发.
标题:实用,不对称合成丙型肝炎病毒蛋白酶抑制剂mk-5172的开发.
摘要:描述了实用,不对称合成的丙型肝炎病毒(hcv)蛋白酶抑制剂mk-5172(1)(一种18元大环化合物)的开发.
Doi:10.1021/ol401864T