CAS: 1192651-49-2; (1R,2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide

上下游产品

(2S,5R)-6-(苄氧基)-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-羧酸 (2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylic Acid 1174020-25-7
Methyl (2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1383814-58-1
(2S,5R)-7-氧代-6-(苯基甲氧基)-1,6-二氮杂双环[3.2.1]辛烷-2-羧酸乙酯 (2S,5R)-Ethyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1416134-63-8
(2S,5R)-Allyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1383814-59-2
(2S,5R)-Tert-Butyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1383814-56-9
(2S,5R)-Benzyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1416134-61-6
2,5-Dioxopyrrolidin-1-Yl (2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1383814-60-5
Trans-5-(Benzyloxyamino)-2-Carbamoylpiperidine-1-Carboxylic Acid Tert-Butyl Ester 1426572-83-9 (2S,5R)-Tert-Butyl 5-(Benzyloxyamino)-1-(2,2,2-Trifluoroacetyl)Piperidine-2-Carboxylate 1383814-54-7

(2S,5S)-Tert-Butyl 5-Hydroxypiperidine-2-Carboxylate置于n-甲基吗啉,2,6-二甲基吡啶,Sodium Dihydrogenphosphate,三氟甲磺酸酐,氨,三乙胺,三氟乙酸,Sodium Hydroxide,氯甲酸异丁酯体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,水,乙腈 用作溶剂,化学反应 96.67H,反应生成(1R,2S,5R)-7-氧代-6-(苄氧基)-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺
参考文献:Optically Active Diazabicyclooctane Derivatives And Process For Preparing The Same
标题:Optically Active Diazabicyclooctane Derivatives And Process For Preparing The Same
摘要:提供了一个光学活性的二氮杂双环辛烷衍生物,其由下面的式(f)定义,可用作β-内酰胺酶抑制剂的药用中间体,以及制备该衍生物的方法.在上述的式(f)中,R1代表co2R,Co2M或conh2,其中r代表甲基基团,叔丁基基团,烯丙基团,苄基团或2,5-二氧代吡咯烷-1-基团,M代表氢原子,无机阳离子或有机阳离子;R2代表苄基团或烯丙基团.

专利信息

专利号:WO-2025027521-A1
优先权日:2023-08-01
标题 :An improved process for the preparation of avibactam and intermediate thereof
发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.

专利号:CN-115073459-A
优先权日:2022-07-07
标 题 :A kind of continuous flow synthesis method of avibactam sodium intermediate