CAS: 108749-08-2; 1,2,3,4-Tetrahydro-2,7-Naphthyridine

该化合物是一种双环有机化合物,其特点是其引信环状结构,包括环环状框架中的氮原子,该化合物属于环状环状动物类,该物质是环状系统中含有氮原子的氯化萘衍生物.四氢化合物的存在表明该化合物完全饱和,这意味着其环状结构内没有双环状化合物.这种饱和有助于其稳定性和影响其再活性.该化合物一般无色至浅黄色,可能表现出一种独特的气味.有机溶剂中溶解,许多含氮的异性循环中常见. 1,3,4,4-四氢-[2,7,7-甲苯丙丙胺在医药化学中具有潜在用途,特别是制药业,因为其结构上与生物活性化合物相似.其特性,如熔点,沸点和特定再活性,可能因亚基成分的存在和合成或使用的条件而不同.

结构式图片

相似化合物

1354940-72-9 1335053-26-3 449175-32-0

物理性质

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上下游产品

CAS号27224-97-1 1,3,6,8-四氯-2,7-萘啶 | CAS号253-45-2 2,7-萘啶 | CAS号105-50-0 丙酮二羧酸二乙酯 | CAS号885270-18-8 八氢-2,7-萘啶-2(1h)...

合成工艺路线路线简述

    📜3-氰基-4-甲基吡啶置于dimethyl Sulfide Borane,氢气,Sodium Hydride体系中,用 四氢呋喃,乙醇,二氯甲烷,水 用作溶剂,60.0 °C,344.75 Kpa 条件下,反应 48.0H,反应生成1,2,3,4-四氢-2,7-萘啶
    参考文献: Prmt5 Inhibitors And Uses Thereof[fr] Inhibiteurs De Prmt5 Et Leurs Utilisations
    标题: Prmt5 Inhibitors And Uses Thereof[fr] Inhibiteurs De Prmt5 Et Leurs Utilisations

    专利信息


    专利号:US-12319691-B2
    优先权日:2020-05-04
    标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
    发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
    权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

    专利号:EA-030907-B1
    优先权日:2013-12-24
    标题 :ANALOGUES OF CORTISTATIN, THEIR SYNTHESIS AND APPLICATIONS

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    合成参考文献


    参考文献:10.1007/s10593-012-1088-x
    摘要:Abele R, Belyakov S, Jansone D, Abele E. Novel rearrangement of 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-nitrile in the presence of POCl3. Chemistry of Heterocyclic Compounds. 2012 Sep 27;48(6):977–80. doi: 10.1007/s10593-012-1088-x.
    参考文献:10.1007/s10593-012-1017-z
    摘要:Sirakanyan SN, Avetisyan NG, Noravyan AS. New heterocyclic systems based on 1-hydrazino-5,6,7,8-tetrahydro[2,7]naphthyridine: 7,8,9,10-tetra-hydro[1,2,4]triazolo[3,4-a]- and 7,8,9,10-tetra-hydro[1,2,4]triazolo[5,1-a][2,7]naphthyridines. Chemistry of Heterocyclic Compounds. 2012 Jun;48(3):470–5. doi: 10.1007/s10593-012-1017-z.
    参考文献:10.1134/s1068162022040021
    摘要:Adel M. Kamal El-Dean, Geies AA, Hassanien R, Abdel-Wadood FK, El-Naeem EEA. Novel Synthesis, Reactions, and Biological Study of New Morpholino-Thieno[2,3-c][2,7]Naphthyridines as Anti-Cancer and Anti-Microbial Agents. Russian Journal of Bioorganic Chemistry. 2022 Jul 04;48(4):821–34. doi: 10.1134/s1068162022040021.
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