CAS: 10261-94-6; 3-Nitro-2-Pyridinecarboxaldehyde

相似化合物

36625-64-6 59290-85-6 55234-58-7

上下游产品

CAS号18699-87-1 2-甲基-3-硝基吡啶 | CAS号67-56-1 甲醇 | CAS号5470-18-8 2-氯-3-硝基吡啶 | CAS号65156-92-5 N,N-dimethyl-2-... | CAS号150281-83-7 3-硝基-2-乙烯基吡啶 | CAS号36625-64-6 2-(羟甲基)-3-硝基吡啶 | CAS号931-19-1 2-甲基吡啶-N-氧化物 | CAS号5236-76-0 2-Methyl-3-nitr... | CAS号131747-33-6 2-acetoxymethyl... | CAS号59290-85-6 2-羧酸-3-硝基吡啶 | CAS号143621-35-6 2-[(3-氨基吡啶-2-基)...

📜2-甲基吡啶氧化物置于磷酸,Potassium Carbonate,4-硝基苯甲酰氯,Silver Nitrate,二甲基亚砜,N,N'-二环己基碳二亚胺体系中,用 甲醇 用作溶剂,化学反应 4.0H,反应生成3-硝基吡啶-2-甲醛
参考文献:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
标题:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
摘要:合成了一系列4-(取代的吡啶基)-1,4-二氢吡啶衍生物,并研究了它们的降压作用.几种化合物,2-(n-苄基-N-甲基氨基)乙基甲基1,4-二氢-2,6-二甲基-4-(3-硝基-2-吡啶基)-3,5-吡啶二甲酸(2B),4-(4-硝基-2-吡啶基)类似物(2G),4-(3-三氟甲基-2-吡啶基)类似物(2C),4-(2-三氟甲基-3-吡啶基)类似物(3E),4-发现(4-氰基-2-吡啶基)类似物(2E),4-(2-氰基-3-吡啶基)类似物(3D)和4-(6-溴-2-吡啶基)类似物(2I)具有与尼卡地平类似的降压活动;特别是2C和3E的持续时间约为尼卡地平的两倍,而2E具有在所有合成衍生物中最有效的降压活性.
Doi:10.1248/cpb.38.2446

专利信息

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).