专利号:US-5426206-A 优先权日:1993-11-24 标题 :Stereospecific synthesis of aldols 发明人:JUNG MICHAEL E; D AMICO DERIN C 权利人:UNIV CALIFORNIA 摘要:Methods are provided for preparing all four diastereomers of 2-alkyl-3-hydroxyalkanals, 2-alkyl-3-silyloxyalkanals, and the like, with high enantiocontrol, using non-aldol chemistry. The synthetic methods also provide novel, stereospecific routes to polypropinates and chiral 2-substituted-1,3 diols.
专利号:US-10874646-B2 优先权日:2015-10-16 标 题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof 发明人:NICOLAOU KYRIACOS C; RHOADES DEREK; WANG YANPING; TOTOKOTSOPOULOS SOTIRIOS 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
专利号:FR-2815961-A1 优先权日:2000-10-26 标题:NEW INTERMEDIATES USEFUL FOR THE SYNTHESIS OF RETINOIDS
专利号:US-2019022069-A1 优先权日:2015-10-16 标题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof