CAS: 92466-70-1; Bis(2,2,2-Trifluoroethyl) Phosphonate

该化合物是一种有机磷化合物,其特征是三氟乙基酯组;这种磷衍生物通常用作有机合成的试剂,特别是磷酸化和阻燃剂的前体;其高热稳定性和对水解的耐受性使其适合在严格条件下需要强力性能的应用;三氟乙基组的存在增强了其在核循环替代反应中的回弹性,促进了高效的磷基转化;此外,它作为生产专门农用化学品和药物的中间体;其明确的结构和一贯纯度确保了研究和工业工艺的可靠性能.

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    专利信息


    专利号:US-5426206-A
    优先权日:1993-11-24
    标题 :Stereospecific synthesis of aldols
    发明人:JUNG MICHAEL E; D AMICO DERIN C
    权利人:UNIV CALIFORNIA
    摘要:Methods are provided for preparing all four diastereomers of 2-alkyl-3-hydroxyalkanals, 2-alkyl-3-silyloxyalkanals, and the like, with high enantiocontrol, using non-aldol chemistry. The synthetic methods also provide novel, stereospecific routes to polypropinates and chiral 2-substituted-1,3 diols.

    专利号:US-10874646-B2
    优先权日:2015-10-16
    标 题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
    发明人:NICOLAOU KYRIACOS C; RHOADES DEREK; WANG YANPING; TOTOKOTSOPOULOS SOTIRIOS
    权利人:UNIV RICE WILLIAM M
    摘要:In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

    专利号:FR-2815961-A1
    优先权日:2000-10-26
    标题:NEW INTERMEDIATES USEFUL FOR THE SYNTHESIS OF RETINOIDS

    专利号:US-2019022069-A1
    优先权日:2015-10-16
    标题 :Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof

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    合成参考文献


    摘要:Naka, H.; Saito, S., Science of Synthesis Knowledge Updates, (2010) 4, 81.
    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 215.
    摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 424.
    摘要:Bergin, E., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 576.
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